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Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
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SCHEDULE 13D/A 0000950170-25-016480 0001776851 XXXXXXXX LIVE 2 Common Stock, $0.0001 par value per share 03/04/2025 false 0001681087 8789272108 Tectonic Therapeutic, Inc. 490 Arsenal Way, Suite 210 Watertown MA 02472 Jean-Philippe Kouakou-Zebouah (857) 254-9500 Vida Ventures II, LLC 40 Broad Street, Suite 201 Boston MA 02109 0001776851 N Vida Ventures II, LLC b WC N DE 0 0 0 0 0 N 0.0 OO 0001781930 N Vida Ventures II-A, LLC b WC N DE 0 0 0 0 0 N 0.0 OO 0001824569 N VV Manager II, LLC b AF N DE 0 0 0 0 0 N 0.0 OO Common Stock, $0.0001 par value per share Tectonic Therapeutic, Inc. 490 Arsenal Way, Suite 210 Watertown MA 02472 Explanatory Note: This Amendment No. 2 (this Amendment) amends and supplements the Schedule 13D originally filed by the Reporting Persons with the SEC on June 27, 2024, as amended by that Amendment No. 1 filed with the SEC on February 7, 2025 (collectively, the Original Schedule 13D). Only those items that are hereby reported are amended; all other items reports in the Original Schedule 13D remain unchanged. Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable. Capitalized terms not defines in this Amendment have the meanings ascribed to them in the Original Schedule 13D. The information set forth in Item 2(a) of the Original Schedule 13D is incorporated herein by reference. The information set forth in Item 2(b) of the Original Schedule 13D is incorporated herein by reference. The information set forth in Item 2(c) of the Original Schedule 13D is incorporated herein by reference. The information set forth in Item 2(d) of the Original Schedule 13D is incorporated herein by reference. The information set forth in Item 2(e) of the Original Schedule 13D is incorporated herein by reference. The information set forth in Item 2(f) of the Original Schedule 13D is incorporated herein by reference. The information set forth in Item 3 of the Original Schedule 13D is incorporated herein by reference. The information set forth in Item 4 of the Original Schedule 13D is incorporated herein by reference. See Items 7-11 of the cover pages of this Amendment No. 2. The information reported on such cover pages is reported as of March 4, 2025. See Items 7-11 of the cover pages of this Amendment No. 2. The information reported on such cover pages is reported as of March 4, 2025. On February 14, 2025, Vida II effected a pro rata distribution of 934,949 shares of Common Stock to its members without additional consideration. On February 14, 2025, Vida II-A effected a pro rata distribution of 25,944 shares of Common Stock to its members without additional consideration. On February 18, 2025, Vida II sold 7,881 shares of Common Stock at a weighted average price per share of $33.2498 for aggregate proceeds of approximately $261,577.63.On February 18, 2025, Vida II-A sold 219 shares of Common Stock at a weighted average price per share of $33.2498 for aggregate proceeds of approximately $7,258.52. On February 28, 2025, Vida II sold 20,345 shares of Common Stock at a weighted average price per share of $25.6818 for aggregate proceeds of approximately $521,419.67. On February 28, 2025, Vida II-A sold 565 shares of Common Stock at a weighted average price per share of $25.6818 for aggregate proceeds of approximately $14,468.89. On March 3, 2025, Vida II sold 584 shares of Common Stock at a weighted average price per share of $24.9606 for aggregate proceeds of approximately $14,468.79. On March 3, 2025, Vida II-A sold 16 shares of Common Stock at a weighted average price per share of $24.9606 for aggregate proceeds of approximately $401.49. On March 4, 2025, Vida II sold 37,140 shares of Common Stock at a weighted average price per share of $23.0841 for aggregate proceeds of approximately $855,438.36. On March 4, 2025, Vida II-A sold 1,031 shares of Common Stock at a weighted average price per share of $23.0841 for aggregate proceeds of approximately $23,737.58. The information set forth in Item 5(d) of the Original Schedule 13D is incorporated herein by reference. March 4, 2025 The information set forth in Item 6 of the Original Schedule 13D is incorporated herein by reference. Vida Ventures II, LLC By: VV Manager II, LLC, its Manager, /s/ Jean-Philippe Kouakou-Zebouah Authorized Signatory 04/07/2025 Vida Ventures II-A, LLC By: VV Manager II, LLC, its Manager, /s/ Jean-Philippe Kouakou-Zebouah Authorized Signatory 04/07/2025 VV Manager II, LLC /s/ Jean-Philippe Kouakou-Zebouah Authorized Signatory 04/07/2025