Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
Spruce Biosciences, Inc.
Daly City, California
We hereby consent to the incorporation by reference in the Registration Statement on Form S-8 of our report dated March 14, 2022, relating to the financial statements of Spruce Biosciences, Inc. appearing in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021.
/s/ BDO USA, LLP
San Jose, California
March 14, 2022