Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We hereby consent to the incorporation by reference in this Registration Statement on Form
F-3 of Sol-Gel Technologies Ltd. of our report dated April 29, 2025 relating to the financial statements, which appears in Sol-Gel Technologies Ltd.'s Annual Report on
Form 20-F for the year ended December 31, 2024. We also consent to the reference to us under the heading “Experts” in such Registration Statement.
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Tel-Aviv, Israel
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/s/ Kesselman & Kesselman
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April 29, 2025
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Certified Public Accountants (Isr.)
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A member firm of PricewaterhouseCoopers International Limited
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