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Exhibit 15.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
 
We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (Nos. 333-223915, 333-270477 and 333-286820) and Form F-3 (No. 333-286822) of Sol-Gel Technologies Ltd. of our report dated March 19, 2026  relating to the financial statements, which appears in this Form 20-F.
 
Tel-Aviv, Israel
/s/Kesselman & Kesselman
March 19, 2026
Certified Public Accountants (Isr.)
 
A member firm of PricewaterhouseCoopers International Limited