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S-3 424B5 EX-FILING FEES 333-284016 0001689548 Praxis Precision Medicines, Inc. N/A N/A 0001689548 2025-09-05 2025-09-05 0001689548 1 2025-09-05 2025-09-05 0001689548 2 2025-09-05 2025-09-05 iso4217:USD xbrli:pure xbrli:shares

Calculation of Filing Fee Tables

S-3

Praxis Precision Medicines, Inc.

Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable

Security Type

Security Class Title

Fee Calculation or Carry Forward Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

Carry Forward Form Type

Carry Forward File Number

Carry Forward Initial Effective Date

Filing Fee Previously Paid in Connection with Unsold Securities to be Carried Forward

Newly Registered Securities
Fees to be Paid 1 Equity Common Stock, $0.0001 par value per share 457(o) $ 86,243,413.61 0.0001531 $ 13,203.87
Fees Previously Paid 2 Equity Common Stock, $0.0001 par value per share 457(o) $ 163,756,586.39 $ 25,071.13
Carry Forward Securities
Carry Forward Securities

Total Offering Amounts:

$ 250,000,000.00

$ 38,275.00

Total Fees Previously Paid:

$ 25,071.13

Total Fee Offsets:

$ 0.00

Net Fee Due:

$ 13,203.87

Offering Note

1

The registration fee is calculated in accordance with Rule 457(o) under the Securities Act of 1933, as amended, based on the proposed maximum aggregate offering price.

2

On December 23, 2024, we filed a registration statement on Form S-3 (File No. 333-284016), with the Securities and Exchange Commission, which was effective immediately upon filing, which included a prospectus supplement relating to the offering of the registrant's common stock that may be issued and sold from time to time under the Open Market Sale AgreementSM, dated March 5, 2024 and as amended by certain Amendment No. 1 to Open Market Sale Agreement on December 23, 2024, with Jefferies LLC, (as amended, the "Prior Sales Agreement", and the offering, the "Prior ATM Offering"). On September 2, 2025, we terminated the Prior Sales Agreement and the Prior ATM Offering. We sold $86,243,413.61 of Common Stock under the Prior ATM Offering and $163,756,586.39 of the $250,000,000 of Common Stock (the "Unsold Common Stock") remained unsold at the termination. We previously paid a filing fee of $25,071.13 with respect to the Unsold Common Stock.
Table 2: Fee Offset Claims and Sources ☑Not Applicable
Registrant or Filer Name Form or Filing Type File Number Initial Filing Date Filing Date Fee Offset Claimed Security Type Associated with Fee Offset Claimed Security Title Associated with Fee Offset Claimed Unsold Securities Associated with Fee Offset Claimed Unsold Aggregate Offering Amount Associated with Fee Offset Claimed Fee Paid with Fee Offset Source
Rules 457(b) and 0-11(a)(2)
Fee Offset Claims N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Fee Offset Sources N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Rule 457(p)
Fee Offset Claims N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Fee Offset Sources N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Table 3: Combined Prospectuses ☑Not Applicable

Security Type

Security Class Title

Amount of Securities Previously Registered

Maximum Aggregate Offering Price of Securities Previously Registered

Form Type

File Number

Initial Effective Date

N/A N/A N/A N/A N/A N/A N/A N/A
Narrative Disclosure
The maximum aggregate offering price of the securities to which the prospectus relates is $250,000,000.00. The prospectus is a final prospectus for the related offering.