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SCHEDULE 13D/A 0001699737-25-000027 0001699737 XXXXXXXX LIVE 1 Common Stock, $0.0001 par value per share 01/09/2026 false 0001847367 022307102 ALUMIS INC. 280 East Grand Avenue South San Francisco CA 94080 Abrar Hussain (650) 285-4270 Samsara BioCapital GP, LLC 628 Middlefield Road Palo Alto CA 94301 0001699737 N Samsara BioCapital, L.P. b WC N DE 0.00 4491731.00 0.00 4491731.00 4491731.00 N 3.8 PN 0001888829 N Samsara BioCapital GP, LLC b AF N DE 0.00 4491731.00 0.00 4491731.00 4491731.00 N 3.8 OO 0002086193 N Samsara Opportunity Fund, L.P. b WC N DE 0.00 1853488.00 0.00 1853488.00 1853488.00 N 1.6 PN 0002086456 N Samsara Opportunity Fund GP, LLC b AF N DE 0.00 1853488.00 0.00 1853488.00 1853488.00 N 1.6 OO 0001253170 N Srinivas Akkaraju b AF N X1 0.00 6345219.00 0.00 6345219.00 6345219.00 N 5.4 IN Common Stock, $0.0001 par value per share ALUMIS INC. 280 East Grand Avenue South San Francisco CA 94080 This Amendment No. 1 (this "Amendment No. 1" or this "Schedule 13D/A") amends and supplements the statement on Schedule 13D originally filed with the Securities and Exchange Commission (the "SEC") on November 24, 2025 (the "Statement") by the Reporting Persons. Unless otherwise defined herein, capitalized terms used in this Amendment No. 1 shall have the meanings ascribed to them in the Statement. Unless amended or supplemented below, the information in the Statement remains unchanged. Item 3 of the Statement is hereby amended and supplemented as follows: On November 26, 2025, Samsara Opportunity Fund purchased 48,537 shares of voting common stock at prices ranging from $7.46 to $7.74 and a weighted-average price of $7.64 per share through open market purchases. On November 28, 2025, Samsara Opportunity Fund purchased 38,702 shares of voting common stock at prices ranging from $7.56 to $7.73 and a weighted-average price of $7.64 per share through open market purchases. On December 1, 2025, Samsara Opportunity Fund purchased 86,350 shares of voting common stock at prices ranging from $7.31 to $7.84 and a weighted-average price of $7.46 per share through open market purchases. On December 2, 2025, Samsara Opportunity Fund purchased 96,000 shares of voting common stock at prices ranging from $7.41 to $7.92 and a weighted-average price of $7.55 per share through open market purchases. On December 3, 2025, Samsara Opportunity Fund purchased 100,000 shares of voting common stock at prices ranging from $7.41 to $7.96 and a weighted-average price of $7.75 per share through open market purchases. On December 4, 2025, Samsara Opportunity Fund purchased 66,027 shares of voting common stock at prices ranging from $7.65 to $8.41 and a weighted-average price of $8.18 per share through open market purchases. On December 5, 2025, Samsara Opportunity Fund purchased the following shares of voting common stock in open market transactions: - 64,969 shares at prices ranging from $8.48 to $9.4793 per share (a weighted-average price of $8.95 per share); - 70,028 shares at prices ranging from $9.48 to $10.47 per share (a weighted-average price of $10.01 per share); and - 51,380 shares at prices ranging from $10.48 to $11.005 per share (a weighted-average price of $10.73 per share). On January 9, 2026, Samsara Opportunity Fund purchased 588,235 shares of voting common stock at a price of $17.00 per share from the underwriters of the Issuer's public offering (the "January 2026 Offering"). The aggregate purchase price for all securities acquired by Samsara Opportunity Fund from November 26, 2025 through January 9, 2026 was $15,209,937.96. Samsara Opportunity Fund funded its purchase of the foregoing securities from capital contributions from its general and limited partners. Rows 11 and 13 of each Reporting Person's cover page to this Schedule 13D/A set forth the aggregate number of shares of voting common stock and percentages of the shares of voting common stock beneficially owned by such Reporting Person and are incorporated by reference. The percentage set forth in each row 13 is based upon the sum of (i) 97,208,495 shares of voting common stock outstanding as of November 6, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 13, 2025 and (ii) 20,297,500 shares of voting common stock issued in the January 2026 Offering, as reported in the Issuer's Current Report on Form 8-K filed with the SEC on January 9, 2026. The Reporting Persons' beneficial ownership of the Issuer's securities consists of (i) 4,491,731 shares of voting common stock directly held by Samsara LP; and (ii) 1,853,488 shares of voting common stock directly held by Samsara Opportunity Fund. Samsara GP is the sole general partner of Samsara LP and Dr. Akkaraju is the managing member of Samsara GP. Each of Samsara GP and Dr. Akkaraju possesses power to direct the voting and disposition of the securities held by Samsara LP. Samsara Opportunity GP is the sole general partner of Samsara Opportunity Fund and Dr. Akkaraju is the managing member of Samsara Opportunity GP. Each of Samsara Opportunity GP and Dr. Akkaraju possesses power to direct the voting and disposition of the securities held by Samsara Opportunity Fund. Rows 7 through 10 of each Reporting Person's cover page to this Schedule 13D/A set forth the number of shares of voting common stock as to which such Reporting Person has the sole or shared power to vote or direct the vote and sole or shared power to dispose or to direct the disposition and are incorporated by reference. Except as set forth herein, none of the Reporting Persons has effected any transactions with respect to the securities of the Issuer since the filing of the Statement. No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, the securities beneficially owned by any of the Reporting Persons. Not applicable. Exhibit 99.1 Joint Filing Agreement (incorporated by reference to Exhibit 99.1 to the Reporting Persons' Schedule 13D filed with the SEC on November 24, 2025). Samsara BioCapital, L.P. /s/ Srinivas Akkaraju By Samsara BioCapital GP, LLC, its General Partner, By Srinivas Akkaraju, Managing Member 01/13/2026 Samsara BioCapital GP, LLC /s/ Srinivas Akkaraju By Srinivas Akkaraju, Managing Member 01/13/2026 Samsara Opportunity Fund, L.P. /s/ Srinivas Akkaraju By Samsara Opportunity Fund GP, LLC, its General Partner, By Srinivas Akkaraju, Managing Member 01/13/2026 Samsara Opportunity Fund GP, LLC /s/ Srinivas Akkaraju By Srinivas Akkaraju, Managing Member 01/13/2026 Srinivas Akkaraju /s/ Srinivas Akkaraju Srinivas Akkaraju 01/13/2026