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Exhibit 5.1

April 17, 2025

Serina Therapeutics, Inc.

601 Genome Way

Suite 201

Huntsville, Alabama 35806

Ladies and Gentlemen:

We have acted as counsel to Serina Therapeutics, Inc., a Delaware corporation (the “Corporation”), with respect to certain legal matters in connection with the filing with the Securities and Exchange Commission (the “Commission”) of a registration statement on Form S-3 (the “Registration Statement”) under the Securities Act of 1933, as amended (the “Securities Act”)

The Registration Statement relates to the resale by certain stockholders and warrant holders of the Corporation named in the Registration Statement (the “Selling Securityholders”), from time to time, of up to (i) 755,728 shares (the “Replacement Warrant Shares”) of the Corporation’s common stock, par value $0.0001 (“Serina common stock”), issuable to certain Selling Securityholders upon the exercise of 755,728 warrants (the “Replacement Incentive Warrants”) issued pursuant to that certain Warrant Agreement, by and between the Corporation and a certain Selling Securityholder, dated as of January 31, 2025 (the “Replacement Warrant Agreement”), (ii) 3,267,189 shares of Serina common stock (the “Secondary Shares”) held of record by the Selling Securityholders, (iii) 962,250 shares of Serina common stock (the “Conversion Shares”) issuable to certain Selling Securityholders upon conversion of 962,250 shares of the Corporation’s Series A Convertible Preferred Stock, par value $0.0001 (the “Series A Preferred Stock”), (iv) 230,940 shares of Serina common stock (the “PIK Shares”) issuable to Selling Securityholders holding Series A Preferred Stock and (v) 377,865 shares of Serina common stock (the “Original Warrant Shares” and together with the Original Warrant Shares, Secondary Shares, Conversion Shares and the PIK Shares, the “Securities”) issuable to certain Selling Securityholders upon the exercise of 377,865 warrants (the “Original Incentive Warrants”) issued pursuant to that certain Warrant Agreement, by and between the Corporation and Equiniti Trust Company LLC as warrant agent, dated as of March 19, 2024 (the “Original Warrant Agreement”).

In our capacity as your counsel in the connection referred to above and as a basis for the opinion hereinafter expressed, we have examined (i) the First Amended and Restated Certificate of Incorporation of the Corporation, as amended to date (the “Certificate of Incorporation”), (ii) the Amended and Restated Bylaws of the Corporation, as amended to date (the “Bylaws’) (iii) the Replace Warrant Agreement, (iv) the Original Warrant Agreement, (v) the Certificate of Designations of Preferences, Rights and Limitations of Series A Convertible Preferred Stock of the Corporation, as amended to date (the “Certificate of Designations”), (vi) originals, or copies certified or otherwise identified, of the Corporation, including minute books of the Corporation as furnished to us by the Corporation, (vii) originals, or copies certified or otherwise identified, of certificates of public officials and of representatives of the Corporation and other instruments and documents, and (viii) the Registration Statement and the prospectus contained therein. We have also examined originals, or copies certified to

our satisfaction, of such other documents, records, certificates, memoranda, and other instruments as in our judgment are necessary or appropriate to enable us to render the opinion expressed below.

For purposes of this opinion, we have assumed the authenticity of all documents submitted to us as originals, the conformity to the originals of all documents submitted to us as copies and the authenticity of the originals of all documents submitted to us as copies. We have also assumed the legal capacity of all natural persons, the genuineness of the signatures of persons signing all documents in connection with which this opinion is rendered, the authority of such persons signing on behalf of the parties thereto other than the Corporation and the due authorization, execution and delivery of all documents by the parties thereto other than the Corporation. We have not independently established or verified any facts relevant to the opinions expressed herein, but have relied upon statements and representations of the officers and other representatives of the Corporation.

We have also assumed that:

i.the Registration Statement and any amendments thereto (including post-effective amendments) will be effective and will comply with all applicable laws at the time the Securities are offered or issued as contemplated by the Registration Statement and that no stop order shall have been issued with respect thereto;

ii.all Securities will be issued and sold in compliance with applicable federal and state securities laws and in the manner stated in the Registration Statement;

iii.the Securities will be issued and sold in the form and containing the terms set forth in the Registration Statement;

iv.the Securities offered do not violate any law applicable to the Corporation, or result in a default under or breach of any agreement or instrument binding upon the Corporation;

v.the Corporation will have obtained any legally required consents, approvals, authorizations, and other orders of the Commission and any other regulatory authorities necessary to issue and sell the Securities being offered;

vi.with respect to shares of Serina common stock offered or purchasable upon exercise or conversion of the Replacement Incentive Warrants, Original Incentive Warrants and Series A Preferred Stock, that there will be sufficient shares of Serina common stock authorized under the Certificate of Incorporation that are not otherwise reserved for issuance;

vii.that no future amendments will be made to the Certificate of Incorporation or Bylaws that would be in conflict with or inconsistent with the Corporation’s right and ability to issue the Securities; and

viii.the Securities offered will comply with all requirements and restrictions, if any, applicable to the Corporation, whether imposed by any court or governmental or regulatory body having jurisdiction over the Corporation.

Based upon and subject to the foregoing qualifications, assumptions and limitations and the further limitations set forth below, we are of the opinion that, (i) the Replacement Warrant Shares, when issued and sold by the Corporation upon valid exercise of the Replacement Incentive Warrants in accordance with the terms thereof and the Replacement Warrant Agreement, including, without limitation, payment of the consideration thereof described in the Replacement Warrant Agreement, will be validly issued,

fully paid and nonassessable, (ii) the Original Warrant Shares, when issued and sold by the Corporation upon valid exercise of the Original Incentive Warrants in accordance with the terms thereof and the Original Warrant Agreement, including, without limitation, payment of the consideration thereof described in the Original Warrant Agreement, will be validly issued, fully paid and nonassessable (iii) the Secondary Shares are validly issued, fully paid and nonassessable, (iv) the Conversion Shares, when and if issued and delivered upon the valid conversion of shares of Series A Preferred Stock in accordance with the Certificate of Designations, will be validly issued, fully paid and nonassessable and (v) the PIK Shares, when and if issued and delivered in accordance with the Certificate of Designations, Certificate of Incorporation and Bylaws, will be validly issued, fully paid and nonassessable.

Our opinions expressed above are subject to the qualification that we express no opinion to the extent that, notwithstanding the Corporation’s current reservation of shares of Serina common stock, future issuances of securities of the Corporation, including the Securities and/or antidilution adjustments to outstanding securities of the Corporation, may cause the Original Incentive Warrants, Replacement Incentive Warrants or Series A Preferred Stock to be exercisable or redeemable for more shares of Serina common stock than the number that then remain authorized but unissued.

Our opinion expressed above is subject to the qualifications that we express no opinion as to the applicability of, compliance with, or effect of any laws except the Delaware General Corporation Law (“DGCL”) and the laws of the State of New York.

We do not find it necessary for the purposes of this opinion, and accordingly we do not purport to cover herein, the application of the securities or “Blue Sky” laws of the various states to the issuance of the Securities.

This opinion is limited to the specific issues addressed herein, and no opinion may be inferred or implied beyond that expressly stated herein. This opinion speaks only as of the date hereof and we assume no obligation to revise or supplement this opinion should the DGCL or the laws of the State of New York be changed by legislative action, judicial decision or otherwise.

This opinion is furnished to you in connection with the filing of the Registration Statement in accordance with the requirements of Item 601(b)(5) of Regulation S-K under the Securities Act, and is not to be used, circulated, quoted or otherwise relied upon for any other purpose.

We hereby consent to the filing of this opinion as Exhibit 5.1 to the Registration Statement. We also consent to the reference to our firm under the heading “Legal Matters” in the Registration Statement. In giving this consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Commission.


Very truly yours,


/s/ Bradley Arant Boult Cummings LLP