NUCANA PLC
3 Lochside Way
Edinburgh, EH12 9DT
United Kingdom
May 5, 2025
VIA EDGAR
U.S. Securities and Exchange Commission
Division of Corporation Finance
Office of Life Sciences
100 F Street, N.E. Washington, D.C. 20549
Attention: Joshua Gorsky and Tim Buchmiller
| Re: | NuCana plc | |
| Registration Statement on Form F-1, as amended | ||
| File No. 333-286716 (the “Registration Statement”) | ||
| Acceleration Request |
Ladies and Gentlemen:
In accordance with Rule 461 of the Rules and Regulations promulgated under the Securities Act of 1933, as amended, NuCana plc (the “Registrant”) hereby respectfully requests that the Securities and Exchange Commission accelerate the effective date of the above-referenced Registration Statement to Monday, May 5, 2025, at 5:00 p.m., Eastern Time, or as soon as thereafter practicable.
The cooperation of the staff in meeting the timetable described above is very much appreciated.
Please contact John T. Rudy of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel to the Registrant, at (617) 348-3050 with any questions regarding this request.
| Very truly yours, |
| NUCANA PLC |
| /s/ Hugh S. Griffith |
| Hugh S. Griffith Chief Executive Officer |
| cc: | Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. |
John T. Rudy, Esq.