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Exhibit 107

Calculation of Filing Fee Tables

424(b)(5)

(Form Type)

Denali Therapeutics Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1 – Newly Registered and Carry Forward Securities

			Security Type			Security Class Title			Fee Calculation or Carry Forward Rule			Amount Registered			Proposed Maximum Offering Price Per Unit			Maximum Aggregate Offering Price			Fee Rate			Amount of Registration Fee			Carry Forward Form Type			Carry Forward File Number			Carry Forward Initial Effective Date			Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward
Newly Registered Securities
Fees to Be Paid			Equity			Common Stock, $0.01 par value per share			Rule 457(r) (1)			11,933,962 (2)			$26.50			$316,249,993			0.00011020			$34,850.75
Fees Previously Paid			—			—			—			—			—			—						—
Carry Forward Securities
Carry Forward Securities			—			—			—			—						—									—			—			—			—
			Total Offering Amounts															$316,249,993						$34,850.75
			Total Fees Previously Paid																					—
			Total Fee Offsets																					—
			Net Fee Due																					$34,850.75

(1)Calculated in accordance with Rule 457(r) under the Securities Act of 1933, as amended (the “Securities Act”). The fee payable in connection with the offering pursuant to this prospectus supplement is being paid herewith in accordance with Rule 456(b) under the Securities Act, and represents deferred payment of the registration fees in connection with the registrant’s Registration Statement on Form S-3ASR (Registration No. 333-263107).

(2)Includes 1,556,603 shares of common stock that the underwriters have an option to purchase.