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Consent of TD Securities (USA) LLC

The Board of Directors

Personalis, Inc.

6600 Dumbarton Circle

Fremont, California 94555

The Board of Directors:

We hereby consent to the inclusion of our opinion letter, dated July 19, 2026, to the Board of Directors of Personalis, Inc. (“Personalis”) as Annex C to, and reference to such opinion letter under the headings “SUMMARY TERM SHEET — Opinions of Personalis’ Financial Advisors — Opinion of TD Securities (USA) LLC” and “SPECIAL FACTORS — Opinions of Personalis’ Financial Advisors — Opinion of TD Securities (USA) LLC ” in, the proxy statement/prospectus relating to the proposed transaction involving Personalis and Tempus AI, Inc. (“Tempus”), which proxy statement/prospectus forms a part of the Registration Statement on Form S-4 of Tempus (the “Registration Statement”). By giving such consent, we do not thereby admit that we are experts with respect to any part of such Registration Statement within the meaning of the term “expert” as used in, or that we come within the category of persons whose consent is required under, the Securities Act of 1933, as amended, or the rules and regulations of the Securities and Exchange Commission promulgated thereunder.

 

August 31, 2026