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S-8 S-8 EX-FILING FEES 0001720893 BioXcel Therapeutics, Inc. N/A Fees to be Paid Fees to be Paid Fees to be Paid 0001720893 2026-03-27 2026-03-27 0001720893 1 2026-03-27 2026-03-27 0001720893 2 2026-03-27 2026-03-27 0001720893 3 2026-03-27 2026-03-27 iso4217:USD xbrli:pure xbrli:shares

Calculation of Filing Fee Tables

S-8

BioXcel Therapeutics, Inc.

Table 1: Newly Registered Securities

Security Type

Security Class Title

Fee Calculation Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

1 Equity Common stock, $0.001 par value per share, 2020 Incentive Award Plan Other 119,000 $ 2.01 $ 239,190.00 0.0001381 $ 33.03
2 Equity Common stock, $0.001 par value per share, 2020 Incentive Award Plan Other 774,110 $ 1.435 $ 1,110,847.85 0.0001381 $ 153.41
3 Equity Common stock, $0.001 par value per share, 2020 Employee Stock Purchase Plan Other 223,277 $ 1.435 $ 320,402.49 0.0001381 $ 44.25

Total Offering Amounts:

$ 1,670,440.34

$ 230.69

Total Fee Offsets:

$ 0.00

Net Fee Due:

$ 230.69

Offering Note

1

(a) In accordance with Rule 416(b) under the Securities Act of 1933, as amended (the "Securities Act"), the shares of common stock, par value $0.001 per share (the "Common Stock"), of BioXcel Therapeutics, Inc. (the "Registrant") being registered hereunder include such indeterminate number of shares of the Common Stock as may be issuable with respect to the shares of the Common Stock being registered hereunder as a result of stock splits, stock dividends or similar transactions. (b) Consists of 893,110 shares of the Registrant's Common Stock that were automatically added to the shares authorized for issuance under the Company's 2020 Incentive Award Plan (as amended, the "2020 Plan") on January 1, 2026 pursuant to an "evergreen" provision contained in the 2020 Plan, of which 119,000 shares were issued upon the exercise of stock options at a weighted average exercise price of $2.01 per share.

2

See Note 1(a) (a) Consists of shares reserved for future issuance under the 2020 Plan. (b) Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act, and based $1.435 per share, which represents the average of the high and low prices of the Registrant's Common Stock on March 24, 2026 as reported on The Nasdaq Capital Market.

3

See Note 1(a) and 2(b) (a) Consists of 223,277 shares of the Registrant's Common Stock that were automatically added to the shares authorized for issuance under the Company's 2020 Employee Stock Purchase Plan (as amended, the "2020 ESPP") on January 1, 2026 pursuant to an "evergreen" provision contained in the 2020 ESPP.
Table 2: Fee Offset Claims and Sources ☑Not Applicable
Registrant or Filer Name Form or Filing Type File Number Initial Filing Date Filing Date Fee Offset Claimed Security Type Associated with Fee Offset Claimed Security Title Associated with Fee Offset Claimed Unsold Securities Associated with Fee Offset Claimed Unsold Aggregate Offering Amount Associated with Fee Offset Claimed Fee Paid with Fee Offset Source
Rule 457(p)
Fee Offset Claims
Fee Offset Sources