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Exhibit 15.1

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Consent of Independent Registered Public Accounting Firm

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We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (No. 333-229952) and Form F-3 (No. 333-239047) of NIO Inc. of our report dated April 6, 2021 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in this Form 20-F.

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/s/ PricewaterhouseCoopers Zhong Tian LLP

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Shanghai, the People’s Republic of China

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April 6, 2021

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