| 1 | Names of Reporting Persons
Frazier Life Sciences Public Fund, L.P. |
| 2 | Check the appropriate box if a member of a Group (see instructions)
 (a)
 (b)
|
| 3 | Sec Use Only |
| 4 | Citizenship or Place of Organization
DELAWARE
|
| Number of Shares Beneficially Owned by Each Reporting Person With: | | 5 | Sole Voting Power
0.00 | | 6 | Shared Voting Power
16,205,306.00 | | 7 | Sole Dispositive Power
0.00 | | 8 | Shared Dispositive Power
16,205,306.00 |
|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
16,205,306.00 |
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
 |
| 11 | Percent of class represented by amount in row (9)
4.7 % |
| 12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person: The percentage listed in row 11 is calculated based on the sum of (i) 243,777,920 shares of Common Stock outstanding on March 10, 2026, as set forth in the Issuer's Annual Report on Form 10-K filed with the SEC on March 12, 2026, and (ii) 100,200,000 shares of Common Stock sold by the Issuer on April 16, 2026, as set forth in the Issuer's Prospectus Supplement dated April 14, 2026 filed with the SEC on April 15, 2026.
| 1 | Names of Reporting Persons
FHMLSP, L.P. |
| 2 | Check the appropriate box if a member of a Group (see instructions)
 (a)
 (b)
|
| 3 | Sec Use Only |
| 4 | Citizenship or Place of Organization
DELAWARE
|
| Number of Shares Beneficially Owned by Each Reporting Person With: | | 5 | Sole Voting Power
0.00 | | 6 | Shared Voting Power
16,205,306.00 | | 7 | Sole Dispositive Power
0.00 | | 8 | Shared Dispositive Power
16,205,306.00 |
|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
16,205,306.00 |
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
 |
| 11 | Percent of class represented by amount in row (9)
4.7 % |
| 12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person: The percentage listed in row 11 is calculated based on the sum of (i) 243,777,920 shares of Common Stock outstanding on March 10, 2026, as set forth in the Issuer's Annual Report on Form 10-K filed with the SEC on March 12, 2026, and (ii) 100,200,000 shares of Common Stock sold by the Issuer on April 16, 2026, as set forth in the Issuer's Prospectus Supplement dated April 14, 2026 filed with the SEC on April 15, 2026.
| 1 | Names of Reporting Persons
FHMLSP, L.L.C. |
| 2 | Check the appropriate box if a member of a Group (see instructions)
 (a)
 (b)
|
| 3 | Sec Use Only |
| 4 | Citizenship or Place of Organization
DELAWARE
|
| Number of Shares Beneficially Owned by Each Reporting Person With: | | 5 | Sole Voting Power
0.00 | | 6 | Shared Voting Power
16,205,306.00 | | 7 | Sole Dispositive Power
0.00 | | 8 | Shared Dispositive Power
16,205,306.00 |
|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
16,205,306.00 |
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
 |
| 11 | Percent of class represented by amount in row (9)
4.7 % |
| 12 | Type of Reporting Person (See Instructions)
OO |
Comment for Type of Reporting Person: The percentage listed in row 11 is calculated based on the sum of (i) 243,777,920 shares of Common Stock outstanding on March 10, 2026, as set forth in the Issuer's Annual Report on Form 10-K filed with the SEC on March 12, 2026, and (ii) 100,200,000 shares of Common Stock sold by the Issuer on April 16, 2026, as set forth in the Issuer's Prospectus Supplement dated April 14, 2026 filed with the SEC on April 15, 2026.
| 1 | Names of Reporting Persons
Frazier Life Sciences X, L.P. |
| 2 | Check the appropriate box if a member of a Group (see instructions)
 (a)
 (b)
|
| 3 | Sec Use Only |
| 4 | Citizenship or Place of Organization
DELAWARE
|
| Number of Shares Beneficially Owned by Each Reporting Person With: | | 5 | Sole Voting Power
0.00 | | 6 | Shared Voting Power
306,906.00 | | 7 | Sole Dispositive Power
0.00 | | 8 | Shared Dispositive Power
306,906.00 |
|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
306,906.00 |
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
 |
| 11 | Percent of class represented by amount in row (9)
0.1 % |
| 12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person: The percentage listed in row 11 is calculated based on the sum of (i) 243,777,920 shares of Common Stock outstanding on March 10, 2026, as set forth in the Issuer's Annual Report on Form 10-K filed with the SEC on March 12, 2026, and (ii) 100,200,000 shares of Common Stock sold by the Issuer on April 16, 2026, as set forth in the Issuer's Prospectus Supplement dated April 14, 2026 filed with the SEC on April 15, 2026.
| 1 | Names of Reporting Persons
FHMLS X, L.P. |
| 2 | Check the appropriate box if a member of a Group (see instructions)
 (a)
 (b)
|
| 3 | Sec Use Only |
| 4 | Citizenship or Place of Organization
DELAWARE
|
| Number of Shares Beneficially Owned by Each Reporting Person With: | | 5 | Sole Voting Power
0.00 | | 6 | Shared Voting Power
306,906.00 | | 7 | Sole Dispositive Power
0.00 | | 8 | Shared Dispositive Power
306,906.00 |
|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
306,906.00 |
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
 |
| 11 | Percent of class represented by amount in row (9)
0.1 % |
| 12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person: The percentage listed in row 11 is calculated based on the sum of (i) 243,777,920 shares of Common Stock outstanding on March 10, 2026, as set forth in the Issuer's Annual Report on Form 10-K filed with the SEC on March 12, 2026, and (ii) 100,200,000 shares of Common Stock sold by the Issuer on April 16, 2026, as set forth in the Issuer's Prospectus Supplement dated April 14, 2026 filed with the SEC on April 15, 2026.
| 1 | Names of Reporting Persons
FHMLS X, L.L.C. |
| 2 | Check the appropriate box if a member of a Group (see instructions)
 (a)
 (b)
|
| 3 | Sec Use Only |
| 4 | Citizenship or Place of Organization
DELAWARE
|
| Number of Shares Beneficially Owned by Each Reporting Person With: | | 5 | Sole Voting Power
0.00 | | 6 | Shared Voting Power
306,906.00 | | 7 | Sole Dispositive Power
0.00 | | 8 | Shared Dispositive Power
306,906.00 |
|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
306,906.00 |
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
 |
| 11 | Percent of class represented by amount in row (9)
0.1 % |
| 12 | Type of Reporting Person (See Instructions)
OO |
Comment for Type of Reporting Person: The percentage listed in row 11 is calculated based on the sum of (i) 243,777,920 shares of Common Stock outstanding on March 10, 2026, as set forth in the Issuer's Annual Report on Form 10-K filed with the SEC on March 12, 2026, and (ii) 100,200,000 shares of Common Stock sold by the Issuer on April 16, 2026, as set forth in the Issuer's Prospectus Supplement dated April 14, 2026 filed with the SEC on April 15, 2026.
| 1 | Names of Reporting Persons
Frazier Life Sciences XI, L.P. |
| 2 | Check the appropriate box if a member of a Group (see instructions)
 (a)
 (b)
|
| 3 | Sec Use Only |
| 4 | Citizenship or Place of Organization
DELAWARE
|
| Number of Shares Beneficially Owned by Each Reporting Person With: | | 5 | Sole Voting Power
0.00 | | 6 | Shared Voting Power
722,956.00 | | 7 | Sole Dispositive Power
0.00 | | 8 | Shared Dispositive Power
722,956.00 |
|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
722,956.00 |
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
 |
| 11 | Percent of class represented by amount in row (9)
0.2 % |
| 12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person: The percentage listed in row 11 is calculated based on the sum of (i) 243,777,920 shares of Common Stock outstanding on March 10, 2026, as set forth in the Issuer's Annual Report on Form 10-K filed with the SEC on March 12, 2026, and (ii) 100,200,000 shares of Common Stock sold by the Issuer on April 16, 2026, as set forth in the Issuer's Prospectus Supplement dated April 14, 2026 filed with the SEC on April 15, 2026.
| 1 | Names of Reporting Persons
FHMLS XI, L.P. |
| 2 | Check the appropriate box if a member of a Group (see instructions)
 (a)
 (b)
|
| 3 | Sec Use Only |
| 4 | Citizenship or Place of Organization
DELAWARE
|
| Number of Shares Beneficially Owned by Each Reporting Person With: | | 5 | Sole Voting Power
0.00 | | 6 | Shared Voting Power
722,956.00 | | 7 | Sole Dispositive Power
0.00 | | 8 | Shared Dispositive Power
722,956.00 |
|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
722,956.00 |
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
 |
| 11 | Percent of class represented by amount in row (9)
0.2 % |
| 12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person: The percentage listed in row 11 is calculated based on the sum of (i) 243,777,920 shares of Common Stock outstanding on March 10, 2026, as set forth in the Issuer's Annual Report on Form 10-K filed with the SEC on March 12, 2026, and (ii) 100,200,000 shares of Common Stock sold by the Issuer on April 16, 2026, as set forth in the Issuer's Prospectus Supplement dated April 14, 2026 filed with the SEC on April 15, 2026.
| 1 | Names of Reporting Persons
FHMLS XI, L.L.C. |
| 2 | Check the appropriate box if a member of a Group (see instructions)
 (a)
 (b)
|
| 3 | Sec Use Only |
| 4 | Citizenship or Place of Organization
DELAWARE
|
| Number of Shares Beneficially Owned by Each Reporting Person With: | | 5 | Sole Voting Power
0.00 | | 6 | Shared Voting Power
722,956.00 | | 7 | Sole Dispositive Power
0.00 | | 8 | Shared Dispositive Power
722,956.00 |
|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
722,956.00 |
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
 |
| 11 | Percent of class represented by amount in row (9)
0.2 % |
| 12 | Type of Reporting Person (See Instructions)
OO |
Comment for Type of Reporting Person: The percentage listed in row 11 is calculated based on the sum of (i) 243,777,920 shares of Common Stock outstanding on March 10, 2026, as set forth in the Issuer's Annual Report on Form 10-K filed with the SEC on March 12, 2026, and (ii) 100,200,000 shares of Common Stock sold by the Issuer on April 16, 2026, as set forth in the Issuer's Prospectus Supplement dated April 14, 2026 filed with the SEC on April 15, 2026.
| 1 | Names of Reporting Persons
Frazier Life Sciences XII, L.P. |
| 2 | Check the appropriate box if a member of a Group (see instructions)
 (a)
 (b)
|
| 3 | Sec Use Only |
| 4 | Citizenship or Place of Organization
DELAWARE
|
| Number of Shares Beneficially Owned by Each Reporting Person With: | | 5 | Sole Voting Power
0.00 | | 6 | Shared Voting Power
1,561,500.00 | | 7 | Sole Dispositive Power
0.00 | | 8 | Shared Dispositive Power
1,561,500.00 |
|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
1,561,500.00 |
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
 |
| 11 | Percent of class represented by amount in row (9)
0.5 % |
| 12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person: The percentage listed in row 11 is calculated based on the sum of (i) 243,777,920 shares of Common Stock outstanding on March 10, 2026, as set forth in the Issuer's Annual Report on Form 10-K filed with the SEC on March 12, 2026, and (ii) 100,200,000 shares of Common Stock sold by the Issuer on April 16, 2026, as set forth in the Issuer's Prospectus Supplement dated April 14, 2026 filed with the SEC on April 15, 2026.
| 1 | Names of Reporting Persons
FHMLS XII, L.P. |
| 2 | Check the appropriate box if a member of a Group (see instructions)
 (a)
 (b)
|
| 3 | Sec Use Only |
| 4 | Citizenship or Place of Organization
DELAWARE
|
| Number of Shares Beneficially Owned by Each Reporting Person With: | | 5 | Sole Voting Power
0.00 | | 6 | Shared Voting Power
1,561,500.00 | | 7 | Sole Dispositive Power
0.00 | | 8 | Shared Dispositive Power
1,561,500.00 |
|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
1,561,500.00 |
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
 |
| 11 | Percent of class represented by amount in row (9)
0.5 % |
| 12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person: The percentage listed in row 11 is calculated based on the sum of (i) 243,777,920 shares of Common Stock outstanding on March 10, 2026, as set forth in the Issuer's Annual Report on Form 10-K filed with the SEC on March 12, 2026, and (ii) 100,200,000 shares of Common Stock sold by the Issuer on April 16, 2026, as set forth in the Issuer's Prospectus Supplement dated April 14, 2026 filed with the SEC on April 15, 2026.
| 1 | Names of Reporting Persons
FHMLS XII, L.L.C. |
| 2 | Check the appropriate box if a member of a Group (see instructions)
 (a)
 (b)
|
| 3 | Sec Use Only |
| 4 | Citizenship or Place of Organization
DELAWARE
|
| Number of Shares Beneficially Owned by Each Reporting Person With: | | 5 | Sole Voting Power
0.00 | | 6 | Shared Voting Power
1,561,500.00 | | 7 | Sole Dispositive Power
0.00 | | 8 | Shared Dispositive Power
1,561,500.00 |
|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
1,561,500.00 |
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
 |
| 11 | Percent of class represented by amount in row (9)
0.5 % |
| 12 | Type of Reporting Person (See Instructions)
OO |
Comment for Type of Reporting Person: The percentage listed in row 11 is calculated based on the sum of (i) 243,777,920 shares of Common Stock outstanding on March 10, 2026, as set forth in the Issuer's Annual Report on Form 10-K filed with the SEC on March 12, 2026, and (ii) 100,200,000 shares of Common Stock sold by the Issuer on April 16, 2026, as set forth in the Issuer's Prospectus Supplement dated April 14, 2026 filed with the SEC on April 15, 2026.
| 1 | Names of Reporting Persons
James N. Topper |
| 2 | Check the appropriate box if a member of a Group (see instructions)
 (a)
 (b)
|
| 3 | Sec Use Only |
| 4 | Citizenship or Place of Organization
UNITED STATES
|
| Number of Shares Beneficially Owned by Each Reporting Person With: | | 5 | Sole Voting Power
0.00 | | 6 | Shared Voting Power
306,906.00 | | 7 | Sole Dispositive Power
0.00 | | 8 | Shared Dispositive Power
306,906.00 |
|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
306,906.00 |
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
 |
| 11 | Percent of class represented by amount in row (9)
0.1 % |
| 12 | Type of Reporting Person (See Instructions)
IN |
Comment for Type of Reporting Person: The amounts reported in rows 6, 8 and 9 represent shares held directly by Frazier Life Sciences X, L.P.
The percentage listed in row 11 is calculated based on the sum of (i) 243,777,920 shares of Common Stock outstanding on March 10, 2026, as set forth in the Issuer's Annual Report on Form 10-K filed with the SEC on March 12, 2026, and (ii) 100,200,000 shares of Common Stock sold by the Issuer on April 16, 2026, as set forth in the Issuer's Prospectus Supplement dated April 14, 2026 filed with the SEC on April 15, 2026.
| 1 | Names of Reporting Persons
Patrick J. Heron |
| 2 | Check the appropriate box if a member of a Group (see instructions)
 (a)
 (b)
|
| 3 | Sec Use Only |
| 4 | Citizenship or Place of Organization
UNITED STATES
|
| Number of Shares Beneficially Owned by Each Reporting Person With: | | 5 | Sole Voting Power
0.00 | | 6 | Shared Voting Power
306,906.00 | | 7 | Sole Dispositive Power
0.00 | | 8 | Shared Dispositive Power
306,906.00 |
|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person
306,906.00 |
| 10 | Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
 |
| 11 | Percent of class represented by amount in row (9)
0.1 % |
| 12 | Type of Reporting Person (See Instructions)
IN |
Comment for Type of Reporting Person: The amounts reported in rows 6, 8 and 9 represent shares held directly by Frazier Life Sciences X, L.P.
The percentage listed in row 11 is calculated based on the sum of (i) 243,777,920 shares of Common Stock outstanding on March 10, 2026, as set forth in the Issuer's Annual Report on Form 10-K filed with the SEC on March 12, 2026, and (ii) 100,200,000 shares of Common Stock sold by the Issuer on April 16, 2026, as set forth in the Issuer's Prospectus Supplement dated April 14, 2026 filed with the SEC on April 15, 2026.