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Exhibit 23.1

 

Consent of Independent Registered Public Accounting Firm

 

 

We consent to the incorporation by reference in the following Registration Statements:

 

 

(1)

Registration Statements (Form S-3 File Nos. 333-268652, 333-281891 and 333-292491) of Compass Therapeutics, Inc., and

 

 

(2)

Registration Statements (Form S-8 No. 333-252103 and 333-286148) of Compass Therapeutics, Inc.;

 

of our report dated March 5, 2026, with respect to the consolidated financial statements of Compass Therapeutics, Inc. and subsidiaries included in this Annual Report (Form 10-K) of Compass Therapeutics, Inc. for the year ended December 31, 2025.

 

/s/ CohnReznick LLP

 

Melville, New York

March 5, 2026