Exhibit 8.1

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Principal Subsidiaries, Consolidated Affiliated Entities and Subsidiaries of Consolidated Affiliated Entities of the Registrant

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Subsidiaries:

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Yao Wang Corporation Limited, a Hong Kong company

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1 Pharmacy Technology (Shanghai) Co., Ltd., a PRC company

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Chongqing Yihao Pharmacy Co., Ltd., a PRC company

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Wuhan Central China Drug Trading Co., Ltd., a PRC company

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Fujian Yaofang Pharmacy Co., Ltd., a PRC company

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Hubei Yihao Pharmacy Co., Ltd., a PRC company

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Liaoning Yihao Pharmacy Co., Ltd., a PRC Company

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Shanghai Hanhong Medical Technology Co., Ltd., a PRC Company

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Shanxi Yihao Yaofang Pharmacy Co., Ltd., a PRC Company

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Tianjin Yihao Pharmacy Co., Ltd., a PRC Company

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Consolidated Affiliated Entities:

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Guangdong Yihao Pharmacy Co., Ltd., a PRC company

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Guangdong Yihao Pharmaceutical Chain Co., Ltd., a PRC company

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Shanghai Yaowang E-Commerce Co., Ltd., a PRC company

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Subsidiaries of Consolidated Affiliated Entities:

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Anshun Southwest Internet Hospital Co., Ltd., a PRC company

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Chengdu Yizhen Internet Hospital Co., Ltd., a PRC company

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Kunshan Yihua Hospital Co., Ltd., a PRC company

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Kunshan Yifang Pharmacy Co., Ltd., a PRC company