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Exhibit 21

Exhibit 21 – Subsidiaries of the Registrant

Listed below are subsidiaries of The Cigna Group as of December 31, 2025 with their jurisdictions of organization. Those subsidiaries not listed would not, in the aggregate, constitute a “significant subsidiary” of The Cigna Group, as that term is defined in Rule 1-02(w) of Regulation S-X.

2025 Subsidiaries Or Affiliates			Jurisdiction
Accredo Health, Incorporated			Delaware
Allegiance Life & Health Insurance Company			Montana
Care Alliance of Florida, LLC			Florida
Care Continuum, Inc.			Kentucky
CareCore NJ, LLC			New Jersey
Chiro Alliance Corporation			Florida
Cigna & CMB Life Insurance Company Limited			China
Cigna Arbor Life Insurance Company			Connecticut
Cigna Dental Health Of California, Inc.			California
Cigna Dental Health Of Colorado, Inc.			Colorado
Cigna Dental Health Of Delaware, Inc.			Delaware
Cigna Dental Health Of Florida, Inc.			Florida
Cigna Dental Health Of Kansas, Inc.			Kansas
Cigna Dental Health Of Kentucky, Inc.			Kentucky
Cigna Dental Health Of Maryland, Inc.			Maryland
Cigna Dental Health Of Missouri, Inc.			Missouri
Cigna Dental Health Of New Jersey, Inc.			New Jersey
Cigna Dental Health Of North Carolina, Inc.			North Carolina
Cigna Dental Health Of Ohio, Inc.			Ohio
Cigna Dental Health Of Pennsylvania, Inc.			Pennsylvania
Cigna Dental Health Of Texas, Inc.			Texas
Cigna Dental Health Of Virginia, Inc.			Virginia
Cigna Dental Health Plan Of Arizona, Inc.			Arizona
Cigna Europe Insurance Company S.A.-N.V.			Belgium
Cigna Global Insurance Company Limited			Guernsey
Cigna Global Reinsurance Company, Ltd.			Bermuda
Cigna Health and Life Insurance Company			Connecticut
Cigna HealthCare of Arizona, Inc.			Arizona
Cigna HealthCare of California, Inc.			California
Cigna HealthCare of Connecticut, Inc.			Connecticut
Cigna HealthCare of Florida, Inc.			Florida
Cigna HealthCare of Georgia, Inc.			Georgia
Cigna HealthCare of Illinois, Inc.			Illinois
Cigna HealthCare of Indiana, Inc.			Indiana
Cigna HealthCare of New Hampshire, Inc.			New Hampshire
Cigna HealthCare of New Jersey, Inc.			New Jersey
Cigna HealthCare of North Carolina, Inc.			North Carolina

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Cigna HealthCare of South Carolina, Inc.			South Carolina
Cigna HealthCare of St. Louis, Inc.			Missouri
Cigna HealthCare of Tennessee, Inc.			Tennessee
Cigna HealthCare of Texas, Inc.			Texas
Cigna Holding Company			Delaware
Cigna Holdings, Inc.			Delaware
Cigna Insurance Middle East S.A.L.			Lebanon
Cigna Life Insurance Company of Canada			Canada
Cigna Life Insurance Company of Europe S.A.-N.V.			Belgium
Cigna Services Middle East FZE			Dubai
Cigna Worldwide General Insurance Company Limited			Hong Kong
Cigna Worldwide Insurance Company			Delaware
Cigna-Evernorth Enterprise Services, Inc.			Delaware
Connecticut General Corporation			Connecticut
Connecticut General Life Insurance Company			Connecticut
CPRx MSO, LLC			Delaware
Evernorth Accountable Care, LLC			Delaware
Evernorth Health, Inc.			Delaware
Evernorth Wholesale Distribution, Inc.			Delaware
Evernorth-VillageMD Care Alliance of NJ, LLC (F/K/A "ENAC of NJ, LLC")			New Jersey
eviCore Healthcare MSI, LLC			Tennessee
Express Scripts Administrators LLC			Delaware
Express Scripts Utilization Management Company			Delaware
Express Scripts, Inc.			Delaware
Inside RX, LLC			Delaware
ManipalCigna Health Insurance Company Limited			India
Matrix Healthcare Services, Inc.			Florida
Medco Health Solutions, Inc.			Delaware
MSI Health Organization of Texas, Inc.			Texas
Pipeline Health Holdings LLC			Delaware
Prohealth Pharmacy Solutions, LLC			Florida
Temple Insurance Company Limited			Bermuda