<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001744816</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>Common Stock, $0.01 par value</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>12/31/2022</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001921865</issuerCik>
        <issuerName>ASP Isotopes Inc.</issuerName>
        <issuerCusip>00218A105</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>601 PENNSYLVANIA AVENUE NW</com:street1>
          <com:street2>SOUTH BUILDING, SUITE 900</com:street2>
          <com:city>WASHINGTON</com:city>
          <com:stateOrCountry>DC</com:stateOrCountry>
          <com:zipCode>20004</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(d)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>Mann Paul Elliot</reportingPersonName>
      <citizenshipOrOrganization>X0</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>5309722.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>5309722.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>5309722.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>14.2</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
      <comments>Items 5, 7 and 9 - 5,087,500 shares of Common Stock held directly by Paul Mann and (2) 222,222 shares of Common Stock issuable upon the exercise of warrants exercisable within 60 days of December 31, 2022.
Item 11- This percentage calculation is based on 35,907,127 outstanding shares as of December 31, 2022.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>ASP Isotopes Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>601 PENNSYLVANIA AVENUE NW, SOUTH BUILDING, SUITE 900, WASHINGTON, DISTRICT OF COLUMBIA, 20004.</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Paul E. Mann</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>601 Pennsylvania Avenue NW, South Building, Suite 900, Washington DC 20004</principalBusinessOfficeOrResidenceAddress>
        <citizenship>United Kingdom</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>5,309,722 shares</amountBeneficiallyOwned>
        <classPercent>14.2 %</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>5,309,722 shares </solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>5,309,722 shares </solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
        <classOwnership5PercentOrLess>N</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>Y</notApplicableFlag>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>Mann Paul Elliot</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Paul E. Mann</signature>
        <title>Paul E. Mann</title>
        <date>02/14/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>