EQUILLIUM, INC.

2223 Avenida de la Playa, Suite 105

La Jolla, California 92037

September 16, 2025

Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F. Street N.E.

Washington, D.C. 20549-3010

Attention: Jason Drory

 

Re:	Equillium, Inc.

Registration Statement on Form S-3

Filed: September 9, 2025

File No. 333-290138

Ladies and Gentlemen:

Equillium, Inc. (the “Registrant”) hereby requests that the U.S. Securities and Exchange Commission (the “Commission”) take appropriate action to cause the above-referenced Registration Statement on Form S-3 to become effective on September 18, 2025, at 4:00 p.m., Eastern Time, or as soon thereafter as is practicable or at such later time as the Registrant may orally request via telephone call to the staff of the Commission. The Registrant hereby authorizes Dylan Kornbluth of Cooley LLP, counsel to the Registrant, to make such request on its behalf.

Once the Registration Statement has been declared effective, please orally confirm that event with Dylan Kornbluth of Cooley LLP at (858) 550-6173.

[Signature Page Follows]

 

cc:	Penny Tom, Equillium, Inc.

Thomas A. Coll, Esq., Cooley LLP

Dylan S. Kornbluth, Esq., Cooley LLP

 

[COMPANY SIGNATURE PAGE TO ACCELERATION REQUEST]