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Exhibit 107

Calculation of Filing Fee Table
Form S-8
(Form Type)

Cyclerion Therapeutics, Inc.
(Exact Name of Registrant as Specified in its Charter

Table 1: Newly Registered Securities

Security Type
 
Security Class Title
 
Fee Calculation Rule
 
Amount Registered(1)
   
Proposed Maximum Offering Price Per Unit(2)
   
Maximum Aggregate Offering Price(2)
   
Fee Rate
   
Amount of Registration Fee
 
                                       
Equity
 
Common Stock, no par value
 
Rule 457(c) and Rule 457(h)
   
2,088,988(3
)
 
$
0.93
   
$
1,942,758.84
     
.0000927
   
$
180.10  
                                                 
Equity
 
Common Stock, no par value
 
Rule 457(c) and Rule 457(h)
   
522,247(4
)
 
$
0.93
   
$
485,689.71      
.0000927
   
$
45.02  
                                                 
Total Offering Amounts
                           
$
225.12
 
                                   
Total Fee Offsets
                           
$
0.00
 
                                   
Net Fee Due
                           
$
225.12
 

(1)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the “Securities Act”), this registration statement also covers such additional shares of Common Stock as may be issued to prevent dilution resulting from stock splits, stock dividends and similar transactions.
 
(2)
Pursuant to Rules 457(c) and 457(h)(1) under the Securities Act, the proposed maximum offering price per unit and the maximum aggregate offering price have been calculated solely for the purpose of computing the registration fee on the basis of the average of the high ($0.96) and low ($0.89) prices of the Common Stock of Cyclerion Therapeutics, Inc. on the Nasdaq Global Select Market on August 5, 2022 ($0.93), such date being within five business days of the date that this registration statement was filed with the Securities and Exchange Commission.
 
(3)
Represents additional shares of Common Stock authorized for issuance under the Cyclerion Therapeutics, Inc. 2019 Equity Incentive Plan.
 
(4)
Represents additional shares of Common Stock authorized for issuance under the Cyclerion Therapeutics, Inc. 2019 Employee Stock Purchase Plan.