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SCHEDULE 13D/A 0001756335 XXXXXXXX LIVE 2 Common shares, Euro 0.12 nominal value per share 10/15/2025 false 0001840748 N51517105 LAVA THERAPEUTICS N.V. Yalelaan 62 Utrecht P7 3584 CM Edwin de Graaf 31 30 219 2565 Cooperatieve Gilde Healthcare IV U.A. Stadsplateau 36 Utrecht P7 P7 3521 AZ 0001756335 N Cooperatieve Gilde Healthcare IV U.A. WC N P7 0 2947781 0 2947781 2947781 N 11.2 OO 0001757508 N Gilde Healthcare IV Management B.V. AF N P7 0 2947781 0 2947781 2947781 N 11.2 OO 0001420106 N Gilde Healthcare Holding B.V. AF N P7 0 2947781 0 2947781 2947781 N 11.2 OO Y Manapouri B.V. AF N P7 0 2947781 0 2947781 2947781 N 11.2 OO Y Martemanshurk B.V. AF N P7 0 2947781 0 2947781 2947781 N 11.2 OO Common shares, Euro 0.12 nominal value per share LAVA THERAPEUTICS N.V. Yalelaan 62 Utrecht P7 3584 CM This Amendment No. 2 ("Amendment No. 2") to Schedule 13D amends the initial Statement on Schedule 13D filed on March 21, 2021, as amended by Amendment No. 1 filed on October 14, 2025 (as so amended, the "Schedule 13D"), relating to the common shares, nominal value Euro 0.12 per share ("Common Shares"), of LAVA Therapeutics N.V., a Netherlands corporation (the "Issuer"). This Amendment No. 2 reflects, among other things, the sales of Common Shares by Cooperatieve Gilde Healthcare IV U.A. ("Gilde Healthcare"). Only those items that are hereby reported are amended; all other items reported in the Schedule 13D remain unchanged. Capitalized terms used but not defined in this Amendment No. 2 shall have the same meanings ascribed to them in the Schedule 13D. Item 4 of the Schedule 13D is hereby amended and supplemented by adding the following: Between October 14, 2025 and October 17, 2025, Gilde Healthcare sold an aggregate of 2,298,711 Common Shares of the Issuer in open market transactions. According to the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission ("SEC") on August 13, 2025, there were 26,305,295 Common Shares outstanding as of August 8, 2025. Gilde Healthcare is the record holder of an aggregate of 2,947,781 Common Shares, which represents beneficial ownership of approximately 11.2% of the outstanding Common Shares as of August 8, 2025. GHCIVM, as the manager of Gilde Healthcare, has the power to vote and dispose of securities held by Gilde Healthcare and may be deemed to beneficially own the securities held of record by Gilde Healthcare. As a result, each of the Reporting Persons may beneficially own 2,947,781 Common Shares, or approximately 11.2% of the outstanding Common Shares. Each Reporting Person has shared power to vote and dispose of 2,947,781 Common Shares. On October 14, 2025, Gilde Healthcare sold 227,341 Common Shares at a weighted average price per share of $1.5092 for aggregate proceeds of approximately $343,103.04. On October 15, 2025, Gilde Healthcare sold 200,000 Common Shares at a weighted average price per share of $1.5070 for aggregate proceeds of approximately $301,400.89. On October 16, 2025, Gilde Healthcare sold 690,239 Common Shares at a weighted average price per share of $1.4936 for aggregate proceeds of approximately $1,030,940.97. On October 17, 2025, Gilde Healthcare sold 1,181,131 Common Shares at a weighted average price per share of $1.4743 for aggregate proceeds of approximately $1,741,341.43. Cooperatieve Gilde Healthcare IV U.A. /s/ Edwin de Graaf Edwin de Graaf/Managing Director of Gilde Healthcare IV Management B.V., as Manager of Cooperatieve Gilde Healthcare IV U.A. 10/17/2025 Gilde Healthcare IV Management B.V. /s/ Edwin de Graaf Edwin de Graaf/Managing Director 10/17/2025 Gilde Healthcare Holding B.V. /s/ Edwin de Graaf Edwin de Graaf/Managing Director 10/17/2025 Manapouri B.V. /s/ Edwin de Graaf Edwin de Graaf/Managing Director 10/17/2025 Martemanshurk B.V. /s/ Pieter van der Meer Pieter van der Meer/Managing Director 10/17/2025