Nanobiotix S.A.

60, rue de Wattignies

75012 Paris, France

February 14, 2022

United States Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

RE: Nanobiotix S.A.

Registration Statement on Form F-3 (File No. 333-262545)

Ladies and Gentlemen:

In accordance with Rules 460 and 461 under the Securities Act of 1933, as amended, Nanobiotix S.A. (the “Registrant”) hereby requests that the Securities and Exchange Commission (the “Commission”) take appropriate action to cause the above-referenced Registration Statement on Form F-3 to become effective on February 16, 2022 at 4:00 p.m., Eastern Time, or as soon thereafter as is practicable.

Once the Registration Statement has been declared effective, please orally confirm the event with Peter Devlin of Jones Day at (212) 326-3978. Thank you for your attention to this matter.

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