Bicycle Therapeutics plc
Blocks A & B, Portway Building
Granta Park Great Abington, Cambridge CB21 6GS
United Kingdom
August 12, 2025
Via Edgar
United States Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549
Attn: Jessica Dickerson
| RE: | Bicycle Therapeutics plc | ||
| Registration Statement on Form S-3 | |||
| File No. 333-289423 | |||
| Acceleration Request | |||
| Requested Date: | August 14, 2025 | ||
| Requested Time: | 4:00 p.m. Eastern Time | ||
Ladies and Gentlemen:
Pursuant to Rule 461 under the Securities Exchange Act of 1933, as amended, the undersigned registrant hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-289423) (the “Registration Statement”) to become effective at 4:00 p.m. Eastern Time on Thursday, August 14, 2025, or as soon thereafter as is practicable.
Once the Registration Statement has been declared effective, please orally confirm that event with Jaime L. Chase of Cooley LLP, counsel to the registrant, at (202) 728-7096.
[Signature page follows]
| Sincerely, | ||
| Bicycle Therapeutics plc | ||
| By: | /s/ Alethia Young | |
| Alethia Young | ||
| Chief Financial Officer | ||
| cc: | Kevin Lee, Chief Executive Officer, Bicycle Therapeutics plc | |
| Laura A. Berezin, Cooley LLP | ||
| Jaime L. Chase, Cooley LLP | ||