SEC FORM 3

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SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person^*

Perry Jennifer Scott

(Last)

(First)

(Middle)

C/O BICYCLE THERAPEUTICS PLC

BLOCKS A & B, PORTWAY BUILDING

(Street)

CAMBRIDGE

CB21 6GS

(City)

(State)

(Zip)

2. Date of Event Requiring Statement (Month/Day/Year)
03/17/2026

3. Issuer Name and Ticker or Trading Symbol
BICYCLE THERAPEUTICS PLC [ BCYC ]

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	10% Owner
X	Officer (give title below)	Other (specify below)
	Chief Operating Officer

5. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Ordinary Shares⁽¹⁾	93,872⁽²⁾	D

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivative Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
Employee Stock Option (right to buy)	⁽³⁾	09/01/2032	Ordinary Shares	20,000	$26.45	D
Employee Stock Option (right to buy)	⁽⁴⁾	01/03/2033	Ordinary Shares	3,576	$29.6	D
Employee Stock Option (right to buy)	⁽⁵⁾	03/13/2033	Ordinary Shares	30,000	$20.02	D
Employee Stock Option (right to buy)	⁽⁶⁾	01/02/2034	Ordinary Shares	31,000	$18.08	D
Employee Stock Option (right to buy)	⁽⁷⁾	07/16/2034	Ordinary Shares	58,000	$22.6	D
Employee Stock Option (right to buy)	⁽⁸⁾	01/02/2035	Ordinary Shares	87,000	$14	D
Employee Stock Option (right to buy)	⁽⁹⁾	01/02/2036	Ordinary Shares	100,000	$7.08	D

Explanation of Responses:

1. The Ordinary Shares may be represented by American Depositary Shares, each of which represents one ordinary share.

2. Includes 84,697 restricted share units ("RSUs"). 447 RSUs vest in four equal quarterly installments commencing on April 3, 2026; 8,000 RSUs vest in eight equal quarterly installments commencing on April 2, 2026; 26,250 RSUs vest in twelve equal quarterly installments commencing on April 2, 2026; and 50,000 RSUs vest one-fourth (1/4) on January 2, 2027 and the remaining RSUs vest in twelve equal quarterly installments thereafter.

3. This option vested with respect to one-fourth (1/4) of the total number of shares underlying the option on August 24, 2023 and the remaining shares vested or vest in 36 equal monthly installments thereafter.

4. This option vested with respect to one-fourth (1/4) of the total number of shares underlying the option on January 3, 2024 and the remaining shares vested or vest in 36 equal monthly installments thereafter.

5. This option vested with respect to one-fourth (1/4) of the total number of shares underlying the option on March 13, 2024 and the remaining shares vested or vest in 36 equal monthly installments thereafter.

6. This option vested with respect to one-fourth (1/4) of the total number of shares underlying the option on January 2, 2025 and the remaining shares vested or vest in 36 equal monthly installments thereafter.

7. This option vested with respect to one-fourth (1/4) of the total number of shares underlying the option on July 16, 2025 and the remaining shares vested or vest in 36 equal monthly installments thereafter.

8. This option vested with respect to one-fourth (1/4) of the total number of shares underlying the option on January 2, 2026 and the remaining shares vested or vest in 36 equal monthly installments thereafter.

9. This option vests with respect to one-fourth (1/4) of the total number of shares underlying the option on January 2, 2027 and the remaining shares vest in 36 equal monthly installments thereafter.

	/s/ Travis Thompson, Attorney-in-Fact	03/25/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.