EX-FILING FEES

Exhibit 107

CALCULATION OF FILING FEES TABLE

Form S-8

(Form Type)

Karuna Therapeutics, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered Securities

Security Type

Security Class Title

Fee
Calculation
Rule

Amount
Registered⁽¹⁾

Proposed
Maximum
Offering
Price Per
Share

Maximum
Aggregate
Offering Price

Fee Rate

Amount of
Registration
Fee

Equity

Common Stock, par value
$0.0001 per share

457(h)

1,190,822 ⁽²⁾

$110.07 ⁽³⁾

$131,073,778

$0.0000927

$12,151

Equity

Common Stock, par value
$0.0001 per share

Common Stock, par value $0.0001
per share

297,705 ⁽⁴⁾

$93.56 ⁽⁵⁾

$27,853,280

$0.0000927

$2,582

Total Offering Amount

$158,927,058

$14,733

Total Fee Offsets

Net Fee Due

$158,927,058

$14,733

(1)

Pursuant to Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), this Registration Statement shall also cover any additional shares of common stock which become issuable under the above-named plans by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of our outstanding shares of common stock.

(2)

Represents an automatic annual increase on January 1, 2022 to the number of shares reserved for issuance under the 2019 Stock Option and Incentive Plan (the “2019 Plan”) pursuant to the terms of the 2019 Plan. Shares available for issuance under the 2019 Plan were previously registered on registration statements on Form S-8 filed with the Securities and Exchange Commission on July 2, 2019 (Registration No. 333-232521), March 24, 2020 (Registration No. 333-237360) and February 25, 2021 (Registration No. 333-253501).

(3)

The price of $110.07 per share, which is the average of the high and low sale prices of the Common Stock of the registrant as quoted on the Nasdaq Global Market on February 18, 2022, is set forth solely for purposes of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act, and has been used as these shares are without a fixed price.

(4)

Represents an automatic annual increase on January 1, 2022 to the number of shares reserved for issuance under the 2019 Employee Stock Purchase Plan (the “2019 ESPP”) pursuant to the terms of the 2019 ESPP. Shares available for issuance under the 2019 ESPP were previously registered on registration statements on Form S-8 filed with the Securities and Exchange Commission on July 2, 2019 (Registration No. 333-232521), March 24, 2020 (Registration No. 333-237360) and February 25, 2021 (Registration No. 333-253501).

(5)

The price of $93.56 per share, which is 85% of the average of the high and low sale prices of the Common Stock of the registrant as quoted on the Nasdaq Global Market on February 18, 2022, is set forth solely for purposes of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act, and has been used as these shares are without a fixed price. Pursuant to the 2019 ESPP, the purchase price of the shares of Common Stock reserved for issuance thereunder will be 85% of the fair market value of a share of Common Stock on the first trading day of the offering period or on the exercise date, whichever is less.