![[MISSING IMAGE: lg_mackenzie-bwlr.jpg]](lg_mackenzie-bwlr.jpg) 
        |  | 
                /s/ Saqib Islam
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|  | Saqib Islam Chief Executive Officer |  |  |  |  | 
![[MISSING IMAGE: lg_mackenzie-bwlr.jpg]](lg_mackenzie-bwlr.jpg) 
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![[MISSING IMAGE: lg_mackenzie-bwlr.jpg]](lg_mackenzie-bwlr.jpg) 
          ![[MISSING IMAGE: lg_mackenzie-bwlr.jpg]](lg_mackenzie-bwlr.jpg) 
        | 
                Selected Companies 
               |  |  | 
                EV/2028E Revenue 
                 Trading Multiple |  | |||
| 
                Agios Pharmaceuticals, Inc. 
               |  |  |  |  | 0.4x |  |  | 
| 
                Apellis Pharmaceuticals, Inc. 
               |  |  |  |  | 1.6x |  |  | 
| 
                Arcutis Biotherapeutics, Inc. 
               |  |  |  |  | 2.5x |  |  | 
| 
                Axsome Therapeutics, Inc. 
               |  |  |  |  | 2.7x |  |  | 
| 
                Geron Corporation 
               |  |  |  |  | 0.8x |  |  | 
| 
                ImmunityBio, Inc. 
               |  |  |  |  | 3.1x |  |  | 
| 
                Krystal Biotech, Inc. 
               |  |  |  |  | 4.5x |  |  | 
| 
                TG Therapeutics, Inc. 
               |  |  |  |  | 5.2x |  |  | 
| 
                Tarsus Pharmaceuticals, Inc. 
               |  |  |  |  | 2.4x |  |  | 
| 
                Travere Therapeutics, Inc. 
               |  |  |  |  | 1.8x |  |  | 
| Date Announced |  |  | 
                Target 
               |  |  | 
                Acquiror 
               |  |  | 
                TV/4-Year
                 Forward Revenue |  | |||
| 
                5/10/2023 
               |  |  | CTI BioPharma Corp. |  |  | 
                Swedish Orphan Biovitrum AB 
               |  |  |  |  | 3.5x |  |  | 
| 
                3/13/2023 
               |  |  | Provention Bio, Inc. |  |  | Sanofi S.A. |  |  |  |  | 5.2x |  |  | 
| 
                8/8/2022 
               |  |  | 
                Global Blood Therapeutics, Inc. 
               |  |  | Pfizer Inc. |  |  |  |  | 5.0x |  |  | 
| 
                8/4/2022 
               |  |  | ChemoCentryx, Inc. |  |  | Amgen Inc. |  |  |  |  | 4.1x |  |  | 
| 
                1/19/2022 
               |  |  | Zogenix, Inc. |  |  | UCB S.A. |  |  |  |  | 2.3x |  |  | 
| 
                2/3/2021 
               |  |  | GW Pharmaceuticals plc |  |  | Jazz Pharmaceuticals plc |  |  |  |  | 3.4x |  |  | 
|  |  |  | 
                2025E 
               |  |  | 
                2026E 
               |  |  | 
                2027E 
               |  |  | 
                2028E 
               |  |  | 
                2029E 
               |  |  | 
                2030E 
               |  |  | 
                2031E 
               |  |  | 
                2032E 
               |  |  | 
                2033E 
               |  |  | 
                2034E 
               |  | ||||||||||||||||||||||||||||||
| 
                Net Revenue 
               |  |  |  | $ | 480 |  |  |  |  | $ | 817 |  |  |  |  | $ | 1,176 |  |  |  |  | $ | 1,388 |  |  |  |  | $ | 1,461 |  |  |  |  | $ | 1,547 |  |  |  |  | $ | 1,645 |  |  |  |  | $ | 1,745 |  |  |  |  | $ | 1,821 |  |  |  |  | $ | 1,873 |  |  | 
| 
                Gross Profit 
               |  |  |  | $ | 397 |  |  |  |  | $ | 657 |  |  |  |  | $ | 974 |  |  |  |  | $ | 1,131 |  |  |  |  | $ | 1,193 |  |  |  |  | $ | 1,282 |  |  |  |  | $ | 1,371 |  |  |  |  | $ | 1,454 |  |  |  |  | $ | 1,479 |  |  |  |  | $ | 1,527 |  |  | 
| EBIT(1) |  |  |  | $ | (147) |  |  |  |  | $ | 121 |  |  |  |  | $ | 408 |  |  |  |  | $ | 560 |  |  |  |  | $ | 618 |  |  |  |  | $ | 812 |  |  |  |  | $ | 938 |  |  |  |  | $ | 1,051 |  |  |  |  | $ | 1,103 |  |  |  |  | $ | 1,135 |  |  | 
|  |  |  | 
                2035E 
               |  |  | 
                2036E 
               |  |  | 
                2037E 
               |  |  | 
                2038E 
               |  |  | 
                2039E 
               |  |  | 
                2040E 
               |  |  | 
                2041E 
               |  |  | 
                2042E 
               |  |  | 
                2043E 
               |  | |||||||||||||||||||||||||||
| 
                Net Revenue 
               |  |  |  | $ | 1,896 |  |  |  |  | $ | 1,839 |  |  |  |  | $ | 1,817 |  |  |  |  | $ | 1,849 |  |  |  |  | $ | 1,894 |  |  |  |  | $ | 1,946 |  |  |  |  | $ | 1,995 |  |  |  |  | $ | 2,006 |  |  |  |  | $ | 1,456 |  |  | 
| 
                Gross Profit 
               |  |  |  | $ | 1,584 |  |  |  |  | $ | 1,544 |  |  |  |  | $ | 1,530 |  |  |  |  | $ | 1,557 |  |  |  |  | $ | 1,592 |  |  |  |  | $ | 1,623 |  |  |  |  | $ | 1,672 |  |  |  |  | $ | 1,677 |  |  |  |  | $ | 1,259 |  |  | 
| EBIT(1) |  |  |  | $ | 1,175 |  |  |  |  | $ | 1,144 |  |  |  |  | $ | 1,131 |  |  |  |  | $ | 1,152 |  |  |  |  | $ | 1,176 |  |  |  |  | $ | 1,195 |  |  |  |  | $ | 1,232 |  |  |  |  | $ | 1,230 |  |  |  |  | $ | 928 |  |  | 
|  |  |  | 
                2025E 
               |  |  | 
                2026E 
               |  |  | 
                2027E 
               |  |  | 
                2028E 
               |  |  | 
                2029E 
               |  |  | 
                2030E 
               |  |  | 
                2031E 
               |  |  | 
                2032E 
               |  |  | 
                2033E 
               |  |  | 
                2034E 
               |  | ||||||||||||||||||||||||||||||
| EBIT(1) |  |  |  | $ | (147) |  |  |  |  | $ | 121 |  |  |  |  | $ | 408 |  |  |  |  | $ | 560 |  |  |  |  | $ | 618 |  |  |  |  | $ | 812 |  |  |  |  | $ | 938 |  |  |  |  | $ | 1,051 |  |  |  |  | $ | 1,103 |  |  |  |  | $ | 1,135 |  |  | 
| 
                Less: Tax Expense(2)
               |  |  |  |  | — |  |  |  |  | $ | (27) |  |  |  |  | $ | (90) |  |  |  |  | $ | (123) |  |  |  |  | $ | (136) |  |  |  |  | $ | (179) |  |  |  |  | $ | (206) |  |  |  |  | $ | (231) |  |  |  |  | $ | (243) |  |  |  |  | $ | (250) |  |  | 
| 
                Plus: Depreciation & Amortization 
               |  |  |  | $ | 1 |  |  |  |  | $ | 2 |  |  |  |  | $ | 4 |  |  |  |  | $ | 6 |  |  |  |  | $ | 9 |  |  |  |  | $ | 11 |  |  |  |  | $ | 14 |  |  |  |  | $ | 17 |  |  |  |  | $ | 20 |  |  |  |  | $ | 23 |  |  | 
|  |  |  | 
                2025E 
               |  |  | 
                2026E 
               |  |  | 
                2027E 
               |  |  | 
                2028E 
               |  |  | 
                2029E 
               |  |  | 
                2030E 
               |  |  | 
                2031E 
               |  |  | 
                2032E 
               |  |  | 
                2033E 
               |  |  | 
                2034E 
               |  | ||||||||||||||||||||||||||||||
| 
                Less: Capital Expenditures 
               |  |  |  | $ | (10) |  |  |  |  | $ | (20) |  |  |  |  | $ | (29) |  |  |  |  | $ | (35) |  |  |  |  | $ | (37) |  |  |  |  | $ | (39) |  |  |  |  | $ | (41) |  |  |  |  | $ | (44) |  |  |  |  | $ | (46) |  |  |  |  | $ | (47) |  |  | 
| 
                Less: Changes in Net Working 
                 Capital |  |  |  | $ | (36) |  |  |  |  | $ | (62) |  |  |  |  | $ | (54) |  |  |  |  | $ | (32) |  |  |  |  | $ | (11) |  |  |  |  | $ | (13) |  |  |  |  | $ | (15) |  |  |  |  | $ | (15) |  |  |  |  | $ | (11) |  |  |  |  | $ | (8) |  |  | 
| 
                Unlevered Free Cash Flow(3)
               |  |  |  | $ | (192) |  |  |  |  | $ | 14 |  |  |  |  | $ | 239 |  |  |  |  | $ | 376 |  |  |  |  | $ | 443 |  |  |  |  | $ | 593 |  |  |  |  | $ | 689 |  |  |  |  | $ | 778 |  |  |  |  | $ | 823 |  |  |  |  | $ | 854 |  |  | 
|  |  |  | 
                2035E 
               |  |  | 
                2036E 
               |  |  | 
                2037E 
               |  |  | 
                2038E 
               |  |  | 
                2039E 
               |  |  | 
                2040E 
               |  |  | 
                2041E 
               |  |  | 
                2042E 
               |  |  | 
                2043E 
               |  | |||||||||||||||||||||||||||
| EBIT(1) |  |  |  | $ | 1,175 |  |  |  |  | $ | 1,144 |  |  |  |  | $ | 1,131 |  |  |  |  | $ | 1,152 |  |  |  |  | $ | 1,176 |  |  |  |  | $ | 1,195 |  |  |  |  | $ | 1,232 |  |  |  |  | $ | 1,230 |  |  |  |  | $ | 928 |  |  | 
| 
                Less: Tax Expense(2)
               |  |  |  | $ | (258) |  |  |  |  | $ | (252) |  |  |  |  | $ | (249) |  |  |  |  | $ | (253) |  |  |  |  | $ | (259) |  |  |  |  | $ | (263) |  |  |  |  | $ | (271) |  |  |  |  | $ | (271) |  |  |  |  | $ | (204) |  |  | 
| 
                Plus: Depreciation & Amortization 
               |  |  |  | $ | 26 |  |  |  |  | $ | 29 |  |  |  |  | $ | 32 |  |  |  |  | $ | 35 |  |  |  |  | $ | 39 |  |  |  |  | $ | 41 |  |  |  |  | $ | 43 |  |  |  |  | $ | 45 |  |  |  |  | $ | 45 |  |  | 
| 
                Less: Capital Expenditures 
               |  |  |  | $ | (47) |  |  |  |  | $ | (46) |  |  |  |  | $ | (45) |  |  |  |  | $ | (46) |  |  |  |  | $ | (47) |  |  |  |  | $ | (49) |  |  |  |  | $ | (50) |  |  |  |  | $ | (50) |  |  |  |  | $ | (36) |  |  | 
| 
                Less: Changes in Net Working Capital 
               |  |  |  | $ | (3) |  |  |  |  | $ | 9 |  |  |  |  | $ | 3 |  |  |  |  | $ | (5) |  |  |  |  | $ | (7) |  |  |  |  | $ | (8) |  |  |  |  | $ | (7) |  |  |  |  | $ | (2) |  |  |  |  | $ | 83 |  |  | 
| 
                Unlevered Free Cash Flow(3)
               |  |  |  | $ | 892 |  |  |  |  | $ | 885 |  |  |  |  | $ | 873 |  |  |  |  | $ | 883 |  |  |  |  | $ | 902 |  |  |  |  | $ | 917 |  |  |  |  | $ | 947 |  |  |  |  | $ | 952 |  |  |  |  | $ | 815 |  |  | 
|  |  |  | 
                2025E 
               |  |  | 
                2026E 
               |  |  | 
                2027E 
               |  |  | 
                2028E 
               |  |  | 
                2029E 
               |  |  | 
                2030E 
               |  |  | 
                2031E 
               |  |  | 
                2032E 
               |  |  | 
                2033E 
               |  |  | 
                2034E 
               |  | ||||||||||||||||||||||||||||||
| 
                Net Revenue 
               |  |  |  | $ | 471 |  |  |  |  | $ | 722 |  |  |  |  | $ | 1,089 |  |  |  |  | $ | 1,315 |  |  |  |  | $ | 1,408 |  |  |  |  | $ | 1,467 |  |  |  |  | $ | 1,539 |  |  |  |  | $ | 1,615 |  |  |  |  | $ | 1,668 |  |  |  |  | $ | 1,699 |  |  | 
| 
                Gross Profit 
               |  |  |  | $ | 417 |  |  |  |  | $ | 599 |  |  |  |  | $ | 877 |  |  |  |  | $ | 1,078 |  |  |  |  | $ | 1,188 |  |  |  |  | $ | 1,191 |  |  |  |  | $ | 1,295 |  |  |  |  | $ | 1,359 |  |  |  |  | $ | 1,412 |  |  |  |  | $ | 1,436 |  |  | 
| EBIT(1) |  |  |  | $ | (137) |  |  |  |  | $ | 39 |  |  |  |  | $ | 302 |  |  |  |  | $ | 489 |  |  |  |  | $ | 593 |  |  |  |  | $ | 725 |  |  |  |  | $ | 870 |  |  |  |  | $ | 969 |  |  |  |  | $ | 1,052 |  |  |  |  | $ | 1,064 |  |  | 
|  |  |  | 
                2035E 
               |  |  | 
                2036E 
               |  |  | 
                2037E 
               |  |  | 
                2038E 
               |  |  | 
                2039E 
               |  |  | 
                2040E 
               |  |  | 
                2041E 
               |  |  | 
                2042E 
               |  |  | 
                2043E 
               |  |  | 
                2044E 
               |  | ||||||||||||||||||||||||||||||
| 
                Net Revenue 
               |  |  |  | $ | 1,706 |  |  |  |  | $ | 1,608 |  |  |  |  | $ | 1,616 |  |  |  |  | $ | 1,651 |  |  |  |  | $ | 1,691 |  |  |  |  | $ | 1,735 |  |  |  |  | $ | 1,781 |  |  |  |  | $ | 1,786 |  |  |  |  | $ | 1,257 |  |  |  |  | $ | 433 |  |  | 
| 
                Gross Profit 
               |  |  |  | $ | 1,398 |  |  |  |  | $ | 1,368 |  |  |  |  | $ | 1,376 |  |  |  |  | $ | 1,405 |  |  |  |  | $ | 1,438 |  |  |  |  | $ | 1,463 |  |  |  |  | $ | 1,511 |  |  |  |  | $ | 1,512 |  |  |  |  | $ | 1,105 |  |  |  |  | $ | 406 |  |  | 
| EBIT(1) |  |  |  | $ | 1,012 |  |  |  |  | $ | 996 |  |  |  |  | $ | 1,000 |  |  |  |  | $ | 1,021 |  |  |  |  | $ | 1,044 |  |  |  |  | $ | 1,058 |  |  |  |  | $ | 1,093 |  |  |  |  | $ | 1,088 |  |  |  |  | $ | 801 |  |  |  |  | $ | 300 |  |  | 
|  |  |  | 
                2025E 
               |  |  | 
                2026E 
               |  |  | 
                2027E 
               |  |  | 
                2028E 
               |  |  | 
                2029E 
               |  |  | 
                2030E 
               |  |  | 
                2031E 
               |  |  | 
                2032E 
               |  |  | 
                2033E 
               |  |  | 
                2034E 
               |  | ||||||||||||||||||||||||||||||
| EBIT(1) |  |  |  | $ | (137) |  |  |  |  | $ | 39 |  |  |  |  | $ | 302 |  |  |  |  | $ | 489 |  |  |  |  | $ | 593 |  |  |  |  | $ | 725 |  |  |  |  | $ | 870 |  |  |  |  | $ | 969 |  |  |  |  | $ | 1,052 |  |  |  |  | $ | 1,064 |  |  | 
| 
                Less: Tax Expense(2)
               |  |  |  |  | — |  |  |  |  | $ | (9) |  |  |  |  | $ | (67) |  |  |  |  | $ | (107) |  |  |  |  | $ | (130) |  |  |  |  | $ | (159) |  |  |  |  | $ | (191) |  |  |  |  | $ | (213) |  |  |  |  | $ | (231) |  |  |  |  | $ | (234) |  |  | 
|  |  |  | 
                2025E 
               |  |  | 
                2026E 
               |  |  | 
                2027E 
               |  |  | 
                2028E 
               |  |  | 
                2029E 
               |  |  | 
                2030E 
               |  |  | 
                2031E 
               |  |  | 
                2032E 
               |  |  | 
                2033E 
               |  |  | 
                2034E 
               |  | ||||||||||||||||||||||||||||||
| 
                Plus: Depreciation & Amortization 
               |  |  |  | $ | 1 |  |  |  |  | $ | 2 |  |  |  |  | $ | 4 |  |  |  |  | $ | 6 |  |  |  |  | $ | 8 |  |  |  |  | $ | 11 |  |  |  |  | $ | 13 |  |  |  |  | $ | 16 |  |  |  |  | $ | 19 |  |  |  |  | $ | 21 |  |  | 
| 
                Less: Capital Expenditures 
               |  |  |  | $ | (8) |  |  |  |  | $ | (18) |  |  |  |  | $ | (27) |  |  |  |  | $ | (33) |  |  |  |  | $ | (35) |  |  |  |  | $ | (37) |  |  |  |  | $ | (38) |  |  |  |  | $ | (40) |  |  |  |  | $ | (42) |  |  |  |  | $ | (42) |  |  | 
| 
                Less: Changes in Net Working Capital 
               |  |  |  | $ | (22) |  |  |  |  | $ | (60) |  |  |  |  | $ | (55) |  |  |  |  | $ | (34) |  |  |  |  | $ | (14) |  |  |  |  | $ | (9) |  |  |  |  | $ | (11) |  |  |  |  | $ | (11) |  |  |  |  | $ | (8) |  |  |  |  | $ | (5) |  |  | 
| 
                Unlevered Free Cash Flow(3)
               |  |  |  | $ | (167) |  |  |  |  | $ | (46) |  |  |  |  | $ | 157 |  |  |  |  | $ | 320 |  |  |  |  | $ | 421 |  |  |  |  | $ | 530 |  |  |  |  | $ | 642 |  |  |  |  | $ | 720 |  |  |  |  | $ | 789 |  |  |  |  | $ | 804 |  |  | 
|  |  |  | 
                2035E 
               |  |  | 
                2036E 
               |  |  | 
                2037E 
               |  |  | 
                2038E 
               |  |  | 
                2039E 
               |  |  | 
                2040E 
               |  |  | 
                2041E 
               |  |  | 
                2042E 
               |  |  | 
                2043E 
               |  |  | 
                2044E 
               |  | ||||||||||||||||||||||||||||||
| EBIT(1) |  |  |  | $ | 1,012 |  |  |  |  | $ | 996 |  |  |  |  | $ | 1,000 |  |  |  |  | $ | 1,021 |  |  |  |  | $ | 1,044 |  |  |  |  | $ | 1,058 |  |  |  |  | $ | 1,093 |  |  |  |  | $ | 1,088 |  |  |  |  | $ | 801 |  |  |  |  | $ | 300 |  |  | 
| 
                Less: Tax Expense(2)
               |  |  |  | $ | (223) |  |  |  |  | $ | (219) |  |  |  |  | $ | (220) |  |  |  |  | $ | (225) |  |  |  |  | $ | (230) |  |  |  |  | $ | (233) |  |  |  |  | $ | (241) |  |  |  |  | $ | (239) |  |  |  |  | $ | (176) |  |  |  |  | $ | (66) |  |  | 
| 
                Plus: Depreciation & Amortization 
               |  |  |  | $ | 24 |  |  |  |  | $ | 27 |  |  |  |  | $ | 30 |  |  |  |  | $ | 32 |  |  |  |  | $ | 35 |  |  |  |  | $ | 38 |  |  |  |  | $ | 39 |  |  |  |  | $ | 40 |  |  |  |  | $ | 40 |  |  |  |  | $ | 39 |  |  | 
| 
                Less: Capital 
                 Expenditures |  |  |  | $ | (43) |  |  |  |  | $ | (40) |  |  |  |  | $ | (40) |  |  |  |  | $ | (41) |  |  |  |  | $ | (42) |  |  |  |  | $ | (43) |  |  |  |  | $ | (45) |  |  |  |  | $ | (45) |  |  |  |  | $ | (31) |  |  |  |  | $ | (11) |  |  | 
| 
                Less: Changes in Net Working Capital 
               |  |  |  | $ | (1) |  |  |  |  | $ | 15 |  |  |  |  | $ | (1) |  |  |  |  | $ | (5) |  |  |  |  | $ | (6) |  |  |  |  | $ | (7) |  |  |  |  | $ | (7) |  |  |  |  | $ | (1) |  |  |  |  | $ | 79 |  |  |  |  | $ | 124 |  |  | 
| 
                Unlevered Free Cash Flow(3)
               |  |  |  | $ | 770 |  |  |  |  | $ | 779 |  |  |  |  | $ | 768 |  |  |  |  | $ | 783 |  |  |  |  | $ | 801 |  |  |  |  | $ | 813 |  |  |  |  | $ | 841 |  |  |  |  | $ | 844 |  |  |  |  | $ | 713 |  |  |  |  | $ | 385 |  |  | 
| 
                Name 
               |  |  | 
                Position 
               |  | 
| Saqib Islam, J.D. |  |  | Chief Executive Officer |  | 
| Francis I. Perier, Jr., M.B.A. |  |  | Chief Financial Officer |  | 
| Badreddin Edris, Ph.D. |  |  | Chief Operating Officer |  | 
| Bhavesh Ashar, M.B.A. |  |  | Chief Commercial Officer |  | 
| James Cassidy, M.D., Ph.D. |  |  | Chief Medical Officer |  | 
| Daniel Pichl |  |  | Chief People Officer |  | 
| Herschel S. Weinstein, J.D. |  |  | General Counsel and Secretary |  | 
| Tai-An Lin, Ph.D. |  |  | Chief Scientific Officer |  | 
| 
                Name 
               |  |  |  |  | 
| Carlos Albán |  |  | ||
| Alan Fuhrman |  |  | ||
| Julie Hambleton, M.D. |  |  | ||
| Freda Lewis-Hall, M.D., DFAPA |  |  | ||
| Daniel S. Lynch, M.B.A. |  |  | ||
| Martin Mackay, Ph.D. |  |  | ||
| 
                Name 
               |  |  | 
                Number of 
                 Company Shares Owned |  | |||
| 
                Saqib Islam, J.D. 
               |  |  |  |  | 602,880 |  |  | 
| 
                Francis I. Perier, Jr. , M.B.A. 
               |  |  |  |  | 28,330 |  |  | 
| 
                Badreddin Edris, Ph.D. 
               |  |  |  |  | 102,781 |  |  | 
| 
                Bhavesh Ashar, M.B.A. 
               |  |  |  |  | 19,305 |  |  | 
| 
                James Cassidy, M.D., Ph.D. 
               |  |  |  |  | 33,969 |  |  | 
| 
                Daniel Pichl 
               |  |  |  |  | 15,982 |  |  | 
| 
                Herschel S. Weinstein, J.D. 
               |  |  |  |  | 22,333 |  |  | 
| 
                Tai-An Lin, Ph.D. 
               |  |  |  |  | 6,486 |  |  | 
| 
                Carlos Albán 
               |  |  |  |  | 15,381 |  |  | 
| 
                Alan Fuhrman 
               |  |  |  |  | 14,667 |  |  | 
| 
                Julie Hambleton, M.D. 
               |  |  |  |  | 4,095 |  |  | 
| 
                Freda Lewis-Hall, M.D., DFAPA 
               |  |  |  |  | 14,667 |  |  | 
| 
                Daniel S. Lynch, M.B.A. 
               |  |  |  |  | 82,944 |  |  | 
| 
                Martin Mackay, Ph.D. 
               |  |  |  |  | — |  |  | 
|  |  |  | 
                Vested Company Options 
               |  |  | 
                Unvested Company Options 
               |  | ||||||||||||||||||
| 
                Name 
               |  |  | 
                Number of
                 Shares (#) |  |  | 
                Value
                 ($) |  |  | 
                Number of
                 Shares (#) |  |  | 
                Value
                 ($) |  | ||||||||||||
| Executive Officers |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                Saqib Islam, J.D. 
               |  |  |  |  | 2,041,632 |  |  |  |  |  | 51,352,830 |  |  |  |  |  | 415,930 |  |  |  |  |  | 3,931,556 |  |  | 
| 
                Francis I. Perier, Jr., M.B.A. 
               |  |  |  |  | 668,558 |  |  |  |  |  | 16,585,182 |  |  |  |  |  | 133,406 |  |  |  |  |  | 1,478,547 |  |  | 
| 
                Badreddin Edris, Ph.D. 
               |  |  |  |  | 611,768 |  |  |  |  |  | 11,271,440 |  |  |  |  |  | 265,950 |  |  |  |  |  | 2,913,518 |  |  | 
| 
                Bhavesh Ashar, M.B.A. 
               |  |  |  |  | 260,558 |  |  |  |  |  | 2,315,345 |  |  |  |  |  | 167,767 |  |  |  |  |  | 1,889,310 |  |  | 
| 
                James Cassidy, M.D., Ph.D. 
               |  |  |  |  | 209,188 |  |  |  |  |  | 1,770,774 |  |  |  |  |  | 167,995 |  |  |  |  |  | 1,733,281 |  |  | 
| 
                Daniel Pichl 
               |  |  |  |  | 176,508 |  |  |  |  |  | 712,956 |  |  |  |  |  | 136,537 |  |  |  |  |  | 1,518,352 |  |  | 
| 
                Herschel S. Weinstein, J.D. 
               |  |  |  |  | 292,393 |  |  |  |  |  | 3,013,240 |  |  |  |  |  | 131,348 |  |  |  |  |  | 1,482,260 |  |  | 
| 
                Tai-An Lin, Ph.D. 
               |  |  |  |  | 36,374 |  |  |  |  |  | 768,173 |  |  |  |  |  | 73,872 |  |  |  |  |  | 1,256,809 |  |  | 
| Non-Employee Directors |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                Carlos Albán 
               |  |  |  |  | 54,474 |  |  |  |  |  | 744,837 |  |  |  |  |  | 1,676 |  |  |  |  |  | 30,285 |  |  | 
| 
                Alan Fuhrman 
               |  |  |  |  | 85,753 |  |  |  |  |  | 1,343,973 |  |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Julie Hambleton, M.D. 
               |  |  |  |  | 49,200 |  |  |  |  |  | 336,194 |  |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Freda Lewis-Hall, M.D., DFAPA 
               |  |  |  |  | 85,753 |  |  |  |  |  | 1,343,973 |  |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Daniel S. Lynch, M.B.A. 
               |  |  |  |  | 324,576 |  |  |  |  |  | 12,023,551 |  |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Martin Mackay, Ph.D. 
               |  |  |  |  | 7,361 |  |  |  |  |  | 75,082 |  |  |  |  |  | 22,084 |  |  |  |  |  | 225,256 |  |  | 
|  |  |  | 
                Company RSUs 
               |  | |||||||||
| 
                Name 
               |  |  | 
                Number of
                 Shares (#) |  |  | 
                Value
                 ($) |  | ||||||
| Executive Officers |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                Saqib Islam, J.D. 
               |  |  |  |  | 162,414 |  |  |  |  |  | 7,633,458 |  |  | 
| 
                Francis I. Perier, Jr., M.B.A. 
               |  |  |  |  | 32,559 |  |  |  |  |  | 1,530,273 |  |  | 
| 
                Badreddin Edris, Ph.D. 
               |  |  |  |  | 66,931 |  |  |  |  |  | 3,145,757 |  |  | 
| 
                Bhavesh Ashar, M.B.A. 
               |  |  |  |  | 42,748 |  |  |  |  |  | 2,009,156 |  |  | 
| 
                James Cassidy, M.D., Ph.D. 
               |  |  |  |  | 47,762 |  |  |  |  |  | 2,244,814 |  |  | 
| 
                Daniel Pichl 
               |  |  |  |  | 34,780 |  |  |  |  |  | 1,634,660 |  |  | 
| 
                Herschel S. Weinstein, J.D. 
               |  |  |  |  | 32,906 |  |  |  |  |  | 1,546,582 |  |  | 
| 
                Tai-An Lin, Ph.D. 
               |  |  |  |  | 26,553 |  |  |  |  |  | 1,247,991 |  |  | 
| Non-Employee Directors |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                Carlos Albán 
               |  |  |  |  | 13,480 |  |  |  |  |  | 633,560 |  |  | 
| 
                Alan Fuhrman 
               |  |  |  |  | 10,060 |  |  |  |  |  | 472,820 |  |  | 
| 
                Julie Hambleton, M.D. 
               |  |  |  |  | 10,060 |  |  |  |  |  | 472,820 |  |  | 
| 
                Freda Lewis-Hall, M.D., DFAPA 
               |  |  |  |  | 10,060 |  |  |  |  |  | 472,820 |  |  | 
| 
                Daniel S. Lynch, M.B.A. 
               |  |  |  |  | 10,060 |  |  |  |  |  | 472,820 |  |  | 
| 
                Martin Mackay, Ph.D. 
               |  |  |  |  | 20,023 |  |  |  |  |  | 941,081 |  |  | 
|  |  |  | 
                Company PSUs 
               |  | |||||||||
| 
                Name 
               |  |  | 
                Number of
                 Shares (#) |  |  | 
                Value
                 ($) |  | ||||||
| Executive Officers |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                Saqib Islam, J.D. 
               |  |  |  |  | 579,749 |  |  |  |  |  | 27,248,203 |  |  | 
| 
                Francis I. Perier, Jr., M.B.A. 
               |  |  |  |  | 14,724 |  |  |  |  |  | 692,028 |  |  | 
| 
                Badreddin Edris, Ph.D. 
               |  |  |  |  | 33,778 |  |  |  |  |  | 1,587,566 |  |  | 
| 
                Bhavesh Ashar, M.B.A. 
               |  |  |  |  | 21,654 |  |  |  |  |  | 1,017,738 |  |  | 
| 
                James Cassidy, M.D., Ph.D. 
               |  |  |  |  | 21,654 |  |  |  |  |  | 1,017,738 |  |  | 
| 
                Daniel Pichl 
               |  |  |  |  | 16,023 |  |  |  |  |  | 753,081 |  |  | 
| 
                Herschel S. Weinstein, J.D. 
               |  |  |  |  | 15,157 |  |  |  |  |  | 712,379 |  |  | 
| 
                Tai-An Lin, Ph.D. 
               |  |  |  |  | 8,661 |  |  |  |  |  | 407,067 |  |  | 
|  |  |  | 
                Company PSUs 
               |  | |||||||||
| 
                Name 
               |  |  | 
                Number of
                 Shares (#) |  |  | 
                Value
                 ($) |  | ||||||
| Non-Employee Directors |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                Carlos Albán 
               |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Alan Fuhrman 
               |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Julie Hambleton, M.D. 
               |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Freda Lewis-Hall, M.D., DFAPA 
               |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Daniel S. Lynch, M.B.A. 
               |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Martin Mackay, Ph.D. 
               |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Name 
               |  |  | 
                Cash 
                 ($)(1) |  |  | 
                Equity 
                 ($)(2) |  |  | 
                Perquisites/Benefits 
                 ($)(3) |  |  | 
                Total 
                 ($) |  | ||||||||||||
| 
                Saqib Islam, J.D. 
               |  |  |  |  | 2,800,000 |  |  |  |  |  | 38,813,217 |  |  |  |  |  | 75,378 |  |  |  |  |  | 41,688,595 |  |  | 
| 
                Francis I. Perier, Jr., M.B.A. 
               |  |  |  |  | 765,600 |  |  |  |  |  | 3,700,848 |  |  |  |  |  | 37,689 |  |  |  |  |  | 4,504,137 |  |  | 
| 
                Bhavesh Ashar, M.B.A. 
               |  |  |  |  | 798,950 |  |  |  |  |  | 4,916,204 |  |  |  |  |  | 37,689 |  |  |  |  |  | 5,752,843 |  |  | 
| 
                Badreddin Edris, Ph.D. 
               |  |  |  |  | 1,009,050 |  |  |  |  |  | 7,646,841 |  |  |  |  |  | 37,689 |  |  |  |  |  | 8,693,580 |  |  | 
| 
                James Cassidy, M.D., Ph.D. 
               |  |  |  |  | 798,950 |  |  |  |  |  | 4,995,833 |  |  |  |  |  | 39,813 |  |  |  |  |  | 5,834,596 |  |  | 
|  |  |  | 
                Shares beneficially owned 
               |  | |||||||||
| 
                Name and address of beneficial owner(1)
               |  |  | 
                Number 
               |  |  | 
                Percentage 
               |  | ||||||
| Greater than 5% Stockholders: |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                FMR LLC(2)
               |  |  |  |  | 11,204,799 |  |  |  |  |  | 14.87% |  |  | 
| 
                The Vanguard Group(3)
               |  |  |  |  | 7,082,581 |  |  |  |  |  | 9.40% |  |  | 
| 
                BlackRock, Inc.(4)
               |  |  |  |  | 6,246,071 |  |  |  |  |  | 8.29% |  |  | 
| Named Executive Officers and Directors: |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                Saqib Islam, J.D.(5)
               |  |  |  |  | 2,680,496 |  |  |  |  |  | 3.46% |  |  | 
| 
                Badreddin Edris, Ph.D.(6)
               |  |  |  |  | 736,231 |  |  |  |  |  | * |  |  | 
| 
                Francis I. Perier, Jr., M.B.A.(7)
               |  |  |  |  | 708,474 |  |  |  |  |  | * |  |  | 
| 
                Daniel S. Lynch, M.B.A.(8)
               |  |  |  |  | 407,520 |  |  |  |  |  | * |  |  | 
| 
                Bhavesh Ashar, M.B.A.(9)
               |  |  |  |  | 293,877 |  |  |  |  |  | * |  |  | 
| 
                James Cassidy, M.D., Ph.D.(10)
               |  |  |  |  | 260,763 |  |  |  |  |  | * |  |  | 
| 
                Freda Lewis-Hall, M.D., DFAPA(11)
               |  |  |  |  | 100,420 |  |  |  |  |  | * |  |  | 
| 
                Alan Fuhrman(12)
               |  |  |  |  | 100,420 |  |  |  |  |  | * |  |  | 
| 
                Carlos Albán(13)
               |  |  |  |  | 70,693 |  |  |  |  |  | * |  |  | 
| 
                Julie Hambleton, M.D.(14)
               |  |  |  |  | 53,295 |  |  |  |  |  | * |  |  | 
| 
                Martin Mackay, Ph.D.(15)
               |  |  |  |  | 8,997 |  |  |  |  |  | * |  |  | 
| 
                All executive officers and directors as a group (14 persons)(16)
               |  |  |  |  | 5,997,910 |  |  |  |  |  | 7.96% |  |  | 
|  |  |  | 
                Page 
               |  | |||
| 
                ARTICLE I
               
                The Merger; Closing; Certificate of Merger and Effective Time 
               |  | ||||||
|  |  |  |  | A-1 |  |  | |
|  |  |  |  | A-1 |  |  | |
|  |  |  |  | A-1 |  |  | |
| 
                ARTICLE II
               
                Certificate of Incorporation and Bylaws of the Surviving Corporation; 
                 Directors and Officers of the Surviving Corporation |  | ||||||
|  |  |  |  | A-2 |  |  | |
|  |  |  |  | A-2 |  |  | |
|  |  |  |  | A-2 |  |  | |
|  |  |  |  | A-2 |  |  | |
| 
                ARTICLE III
               
                Effect of the Merger on Capital Stock; Treatment of Equity Awards; 
                 Delivery of Merger Consideration |  | ||||||
|  |  |  |  | A-2 |  |  | |
|  |  |  |  | A-2 |  |  | |
|  |  |  |  | A-4 |  |  | |
|  |  |  |  | A-7 |  |  | |
| 
                ARTICLE IV
               
                Representations and Warranties of the Company 
               |  | ||||||
|  |  |  |  | A-8 |  |  | |
|  |  |  |  | A-8 |  |  | |
|  |  |  |  | A-9 |  |  | |
|  |  |  |  | A-10 |  |  | |
|  |  |  |  | A-11 |  |  | |
|  |  |  |  | A-12 |  |  | |
|  |  |  |  | A-12 |  |  | |
|  |  |  |  | A-12 |  |  | |
|  |  |  |  | A-13 |  |  | |
|  |  |  |  | A-14 |  |  | |
|  |  |  |  | A-14 |  |  | |
|  |  |  |  | A-14 |  |  | |
|  |  |  |  | A-14 |  |  | |
|  |  |  |  | A-16 |  |  | |
|  |  |  |  | A-17 |  |  | |
|  |  |  |  | A-18 |  |  | |
|  |  |  |  | A-18 |  |  | |
|  |  |  |  | A-20 |  |  | |
|  |  |  | 
                Page 
               |  | |||
|  |  |  |  | A-20 |  |  | |
|  |  |  |  | A-22 |  |  | |
|  |  |  |  | A-22 |  |  | |
|  |  |  |  | A-23 |  |  | |
|  |  |  |  | A-24 |  |  | |
|  |  |  |  | A-24 |  |  | |
|  |  |  |  | A-25 |  |  | |
|  |  |  |  | A-25 |  |  | |
|  |  |  |  | A-25 |  |  | |
|  |  |  |  | A-25 |  |  | |
| 
                ARTICLE V
               
                Representations and Warranties of Parent and Merger Sub 
               |  | ||||||
|  |  |  |  | A-26 |  |  | |
|  |  |  |  | A-26 |  |  | |
|  |  |  |  | A-26 |  |  | |
|  |  |  |  | A-26 |  |  | |
|  |  |  |  | A-27 |  |  | |
|  |  |  |  | A-27 |  |  | |
|  |  |  |  | A-27 |  |  | |
|  |  |  |  | A-27 |  |  | |
|  |  |  |  | A-27 |  |  | |
|  |  |  |  | A-27 |  |  | |
| 
                ARTICLE VI
               
                Covenants 
               |  | ||||||
|  |  |  |  | A-28 |  |  | |
|  |  |  |  | A-31 |  |  | |
|  |  |  |  | A-32 |  |  | |
|  |  |  |  | A-35 |  |  | |
|  |  |  |  | A-36 |  |  | |
|  |  |  |  | A-37 |  |  | |
|  |  |  |  | A-38 |  |  | |
|  |  |  |  | A-39 |  |  | |
|  |  |  |  | A-39 |  |  | |
|  |  |  |  | A-40 |  |  | |
|  |  |  |  | A-40 |  |  | |
|  |  |  |  | A-41 |  |  | |
|  |  |  |  | A-43 |  |  | |
|  |  |  |  | A-44 |  |  | |
|  |  |  |  | A-44 |  |  | |
|  |  |  |  | A-44 |  |  | |
|  |  |  |  | A-45 |  |  | |
|  |  |  |  | A-45 |  |  | |
|  |  |  | 
                Page 
               |  | |||
| 
                ARTICLE VII
               
                Conditions 
               |  | ||||||
|  |  |  |  | A-45 |  |  | |
|  |  |  |  | A-46 |  |  | |
|  |  |  |  | A-46 |  |  | |
| 
                ARTICLE VIII
               
                Termination 
               |  | ||||||
|  |  |  |  | A-47 |  |  | |
|  |  |  |  | A-47 |  |  | |
|  |  |  |  | A-48 |  |  | |
|  |  |  |  | A-48 |  |  | |
|  |  |  |  | A-48 |  |  | |
| 
                ARTICLE IX
               
                Miscellaneous and General 
               |  | ||||||
|  |  |  |  | A-50 |  |  | |
|  |  |  |  | A-50 |  |  | |
|  |  |  |  | A-51 |  |  | |
|  |  |  |  | A-51 |  |  | |
|  |  |  |  | A-51 |  |  | |
|  |  |  |  | A-52 |  |  | |
|  |  |  |  | A-52 |  |  | |
|  |  |  |  | A-53 |  |  | |
|  |  |  |  | A-53 |  |  | |
|  |  |  |  | A-53 |  |  | |
|  |  |  |  | A-53 |  |  | |
|  |  |  |  | A-54 |  |  | |
|  |  |  |  | A-54 |  |  | |
|  | Annexes |  |  |  |  | 
|  | Annex A |  |  | Certain Definitions |  | 
|  | Annex B |  |  | Form of Certificate of Incorporation of the Surviving Corporation |  | 
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