X0609 4 2026-07-08 0 0001974640 Apogee Therapeutics, Inc. APGE 0001779990 HENDERSON MICHAEL THOMAS false C/O APOGEE THERAPEUTICS, INC. 1 LETTERMAN DRIVE, BUILDING B SAN FRANCISCO CA 94129 1 1 0 0 Chief Executive Officer 1 Common Stock 2026-07-08 4 S 0 20000 133.63 D 995987 D Common Stock 2026-07-10 4 G 0 75046 0.00 D 920941 D This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $133.52 to $133.70, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. This transaction involves a bona fide gift of securities from the reporting person to a donor advised fund. /s/ Matthew Batters, as attorney-in-fact for Michael Henderson 2026-07-10