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  Exhibit 23.1
   
  Consent of Independent Registered Public Accounting Firm
   
  We consent to the incorporation by reference in the following Registration Statements:
   
  (1)Registration Statement (Form S-8 No. 333-256185) pertaining to the 2019 Equity Incentive Plan and 2021 Employee Stock Purchase Plan of Landos Biopharma, Inc., 
 
   
  (2)Registration Statement (Form S-8 No. 333-263832) pertaining to the 2019 Equity Incentive Plan, 2021 Employee Stock Purchase Plan, and 2022 Inducement Plan, and
 
   
  (3)Registration Statement (Form S-3 No. 333-263836) of Landos Biopharma, Inc.;
 
   
  of our report dated March 23, 2023, with respect to the consolidated financial statements of Landos Biopharma, Inc. included in this Annual Report (Form 10-K) for the year ended December 31, 2022.
   
  /s/ Ernst & Young LLP
  Raleigh, NC
  March 23, 2023