EX-23.1

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Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the following Registration Statements:

(1)

Registration Statement (Form S-8 No. 333-240309) pertaining to the 2020 Performance Incentive Plan, Employee Stock Purchase Plan, and 2015 Equity Incentive Plan of Nkarta, Inc.,

(2)

Registration Statement (Form S-8 No. 333-252134) pertaining to the 2020 Performance Incentive Plan and Employee Stock Purchase Plan of Nkarta, Inc.,

(3)

Registration Statement (Form S-8 No. 333-263650) pertaining to the 2020 Performance Incentive Plan and Employee Stock Purchase Plan of Nkarta, Inc.,

(4)

Registration Statement (Form S-8 No. 333-269164) pertaining to the 2020 Performance Incentive Plan and Employee Stock Purchase Plan of Nkarta, Inc.,

(5)

Registration Statement (Form S-8 No. 333-276361) pertaining to the 2020 Performance Incentive Plan and Employee Stock Purchase Plan of Nkarta, Inc.,

(6)

Registration Statement (Form S-8 No. 333-284111) pertaining to the 2020 Performance Incentive Plan and Employee Stock Purchase Plan of Nkarta, Inc., and

(7)

Registration Statement (Form S-3 No. 333-270680);

of our report dated March 26, 2025, with respect to the financial statements of Nkarta, Inc. included in this Annual Report (Form 10-K) of Nkarta, Inc. for the year ended December 31, 2024.

/s/ Ernst & Young LLP

San Mateo, California

March 26, 2025