Advancing a Robust, Differentiated Cell Therapy Pipeline 1 Notes ： 1. In collaboration with Janssen, Pharmaceutical Companies of Johnson & Johnson. NDMM = Newly Diagnosed Multiple Myeloma. 2. Phase 1 investigator - initiated trial in China 3. IND applications have been cleared by the United States FDA 4. Subject to an exclusive license agreement with Novartis Pharma AG. The safety and efficacy of the agents and/or uses under in ves tigation have not been established. There is no assurance that the agents will receive health authority approval or become commercially available in any country for the uses being investigated. Additionally, as some programs are still confidential, ce rtain candidates may not be included in this list 5. Subject to the terms of Legend Biotech’s collaboration and license agreement with Johnson & Johnson Partner Current Status NDA Phase III Phase II Phase I Pre - Clinical Indication Target Program CARVYKTI®: BCMA - directed Autologous Therapy Patient follow - up NDMM (Front - line) (Transplant Not Intended) (CARTITUDE - 5) (1) BCMA CARVYKTI® Patient follow - up NDMM ( Front - line, Transplant Eligible) (CARTITUDE - 6) (1) Enrolling NDMM ( Front - line, Transplant Not Intended) (CARTITUDE - 10) (1) Autologous Therapies Met primary endpoint, patient follow - up Relapsed/Refractory Gastric & Pancreatic Cancers (3) Claudin 18.2 LB1908 NOVARTIS Met primary endpoint, patient follow - up 2L+ Small Cell Lung Cancer and Large Cell Neuroendocrine Carcinoma (3)(4) DLL3 LB2102 Patient follow - up Relapsed/Refractory Multiple Myeloma (2) GPRC5D LB2401 Patient follow - up Relapsed/Refractory Multiple Myeloma (2) CD19 x GPRC5D LB2402 Patient follow - up Relapsed/Refractory Multiple Myeloma (2) GPRC5D (FAST CAR) LB2403 Enrolling Relapsed/Refractory Multiple Myeloma (2) FcRH5 (FAST CAR) LB2502 Allogeneic Therapies Enrolling Relapsed/Refractory Autoimmune Diseases (2) CD19 x CD70 (CAR - γδ T) LB2404D Enrolling Relapsed/Refractory Autoimmune Diseases (2) CD19 x BCMA (CAR - NK) LB2405 Enrolling Relapsed/Refractory B - cell Non - Hodgkin Lymphoma (2) CD20 (CAR - αβ T) LB2302 Enrolling Relapsed/Refractory B - cell Non - Hodgkin Lymphoma (2) CD19 x CD20 (CAR - γδ T) LB2303 Enrolling Relapsed/Refractory B - cell Non - Hodgkin Lymphoma (2) CD19 x CD20 (CAR - γδ T) LB2406 In Vivo Therapies Enrolling Relapsed/Refractory B - cell Non - Hodgkin Lymphoma (2) CD19 x CD20 LB2501 Enrolling Relapsed/Refractory Multiple Myeloma (2) GPRC5D LB2503 Initiating Relapsed/Refractory Multiple Myeloma (2)(5) BCMA LB2505 Multi - Regional Clinical Trial Multi - Regional Clinical Trial US IND US IND Multi - Regional Single Arm Trial