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S-3 424B2 EX-FILING FEES 333-279905 0001802768 Royalty Pharma plc N/A N/A The prospectus is not a final prospectus for the related offering. 0001802768 2025-09-03 2025-09-03 0001802768 1 2025-09-03 2025-09-03 0001802768 2 2025-09-03 2025-09-03 0001802768 3 2025-09-03 2025-09-03 0001802768 4 2025-09-03 2025-09-03 0001802768 5 2025-09-03 2025-09-03 0001802768 6 2025-09-03 2025-09-03 iso4217:USD xbrli:pure xbrli:shares

Calculation of Filing Fee Tables

S-3

Royalty Pharma plc

Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable

Security Type

Security Class Title

Fee Calculation or Carry Forward Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

Carry Forward Form Type

Carry Forward File Number

Carry Forward Initial Effective Date

Filing Fee Previously Paid in Connection with Unsold Securities to be Carried Forward

Newly Registered Securities
Fees to be Paid 1 Debt 4.450% Senior Notes due 2031 457(r) 600,000,000 $ 593,454,000.00 0.0001531 $ 90,857.81
Fees to be Paid 2 Debt Guarantees of 4.450% Senior Notes due 2031 Other 0.0001531 $ 0.00
Fees to be Paid 3 Debt 5.200% Senior Notes due 2035 457(r) 900,000,000 $ 881,901,000.00 0.0001531 $ 135,019.04
Fees to be Paid 4 Debt Guarantees of 5.200% Senior Notes due 2035 Other 0.0001531 $ 0.00
Fees to be Paid 5 Debt 5.950% Senior Notes due 2055 457(r) 500,000,000 $ 479,120,000.00 0.0001531 $ 73,353.27
Fees to be Paid 6 Debt Guarantees of 5.950% Senior Notes due 2055 Other 0.0001531 $ 0.00
Fees Previously Paid
Carry Forward Securities
Carry Forward Securities

Total Offering Amounts:

$ 1,954,475,000.00

$ 299,230.12

Total Fees Previously Paid:

$ 0.00

Total Fee Offsets:

$ 0.00

Net Fee Due:

$ 299,230.12

Offering Note

1

(1) Royalty Pharma Holdings Ltd and Royalty Pharma Manager LLC provided a guarantee with respect to the 4.450% Senior Notes due 2031, the 5.200% Senior Notes due 2035 and 5.950% Senior Notes due 2055 issued by Royalty Pharma plc. (2) Pursuant to Rule 457(n) under the Securities Act of 1933, as amended, no additional registration fee is due with respect to the guarantees.

2

(1) Royalty Pharma Holdings Ltd and Royalty Pharma Manager LLC provided a guarantee with respect to the 4.450% Senior Notes due 2031, the 5.200% Senior Notes due 2035 and 5.950% Senior Notes due 2055 issued by Royalty Pharma plc. (2) Pursuant to Rule 457(n) under the Securities Act of 1933, as amended, no additional registration fee is due with respect to the guarantees.

3

(1) Royalty Pharma Holdings Ltd and Royalty Pharma Manager LLC provided a guarantee with respect to the 4.450% Senior Notes due 2031, the 5.200% Senior Notes due 2035 and 5.950% Senior Notes due 2055 issued by Royalty Pharma plc. (2) Pursuant to Rule 457(n) under the Securities Act of 1933, as amended, no additional registration fee is due with respect to the guarantees.

4

(1) Royalty Pharma Holdings Ltd and Royalty Pharma Manager LLC provided a guarantee with respect to the 4.450% Senior Notes due 2031, the 5.200% Senior Notes due 2035 and 5.950% Senior Notes due 2055 issued by Royalty Pharma plc. (2) Pursuant to Rule 457(n) under the Securities Act of 1933, as amended, no additional registration fee is due with respect to the guarantees.

5

(1) Royalty Pharma Holdings Ltd and Royalty Pharma Manager LLC provided a guarantee with respect to the 4.450% Senior Notes due 2031, the 5.200% Senior Notes due 2035 and 5.950% Senior Notes due 2055 issued by Royalty Pharma plc. (2) Pursuant to Rule 457(n) under the Securities Act of 1933, as amended, no additional registration fee is due with respect to the guarantees.

6

(1) Royalty Pharma Holdings Ltd and Royalty Pharma Manager LLC provided a guarantee with respect to the 4.450% Senior Notes due 2031, the 5.200% Senior Notes due 2035 and 5.950% Senior Notes due 2055 issued by Royalty Pharma plc. (2) Pursuant to Rule 457(n) under the Securities Act of 1933, as amended, no additional registration fee is due with respect to the guarantees.
Table 2: Fee Offset Claims and Sources ☑Not Applicable
Registrant or Filer Name Form or Filing Type File Number Initial Filing Date Filing Date Fee Offset Claimed Security Type Associated with Fee Offset Claimed Security Title Associated with Fee Offset Claimed Unsold Securities Associated with Fee Offset Claimed Unsold Aggregate Offering Amount Associated with Fee Offset Claimed Fee Paid with Fee Offset Source
Rules 457(b) and 0-11(a)(2)
Fee Offset Claims N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Fee Offset Sources N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Rule 457(p)
Fee Offset Claims N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Fee Offset Sources N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Table 3: Combined Prospectuses ☑Not Applicable

Security Type

Security Class Title

Amount of Securities Previously Registered

Maximum Aggregate Offering Price of Securities Previously Registered

Form Type

File Number

Initial Effective Date

N/A N/A N/A N/A N/A N/A N/A N/A