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Exhibit 21.1

SUBSIDIARIES OF THE REGISTRANT

The following is a list of subsidiaries of Royalty Pharma plc, omitting subsidiaries which, considered in the aggregate, would not constitute a significant subsidiary as of December 31, 2024:

Legal Name of Subsidiary						Jurisdiction of Organization
Royalty Pharma Holdings Ltd						England and Wales
Royalty Pharma Investments 2019 ICAV						Ireland
RPI 2019 Intermediate Finance Trust						Delaware
Royalty Pharma Investments						Ireland
RPI Finance Trust						Delaware
Royalty Pharma Investments 2023 ICAV						Ireland
Royalty Pharma Development Funding, LLC						Delaware