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Pursuant to Rule 416(a) under the Securities Act of 1933, as amended, or the Securities Act, this registration statement shall also cover any additional shares of common stock, par value $0.0001 per share, or the Common Stock, of Cerevel Therapeutics Holdings, Inc., or the Registrant, that become issuable under the Cerevel Therapeutics Holdings, Inc. 2020 Equity Incentive Plan, or the 2020 Plan, or the Cerevel Therapeutics Holdings, Inc. Amended and Restated 2020 Employee Stock Purchase Plan, or the 2020 ESPP, by reason of any stock split, stock dividend, recapitalization or any other similar transaction effected without the receipt of consideration that results in an increase in the number of outstanding shares of Common Stock.

Represents 3,130,045 additional shares of the Registrant’s Common Stock reserved for future issuance under the 2020 Plan on January 1, 2023. Shares available for issuance under the 2020 Plan were previously registered on a registration statement on Form S-8 filed with the Securities and Exchange Commission, or the SEC, on January 4, 2021 (Registration No. 333-251881) and a registration statement on Form S-8 filed with the SEC on March 1, 2022 (Registration No. 333-263158).

Represents 1,565,022 additional shares of the Registrant’s Common Stock reserved for future issuance under the 2020 ESPP on January 1, 2023. Shares available for issuance under the 2020 ESPP were previously registered on a registration statement on Form S-8 filed with the SEC on January 4, 2021 (Registration No. 333-251881) and a registration statement on Form S-8 filed with the SEC on March 1, 2022 (Registration No. 333-263158).

Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act, based upon the average of the high and low prices of the Registrant’s Common Stock as reported on the Nasdaq Capital Market on February 16, 2023, which was $32.735.

Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act, based on 85% of $32.735, the average of the high and low prices of the Registrant’s Common Stock as reported on the Nasdaq Capital Market on February 16, 2023. Pursuant to the 2020 ESPP, the purchase price of the shares of Common Stock reserved for issuance thereunder will be 85% of the fair market value of the Common Stock on the first trading day of the offering period or on the exercise date, whichever is less.