Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in the following Registration Statements:
(1)
Registration Statement (Form S-8 No. 333-254794) pertaining to the 2018 Equity Incentive Plan (Prior Plan), 2021 Equity Incentive Plan, and 2021 Employee Stock Purchase Plan of Design Therapeutics, Inc.,
(2)
Registration Statements (Form S-8 Nos. 333-263427, 333-270527, 333-278064 and 333-285660) pertaining to the 2021 Equity Incentive Plan and 2021 Employee Stock Purchase Plan of Design Therapeutics, Inc., and
(3)
Registration Statement (Form S-3 No. 333-287043) of Design Therapeutics, Inc.
of our report dated March 9, 2026, with respect to the financial statements of Design Therapeutics, Inc., included in this Annual Report (Form 10-K) of Design Therapeutics, Inc. for the year ended December 31, 2025.
/s/ Ernst & Young LLP
San Diego, California
March 9, 2026