Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in this Registration Statement on Form S-8 of our report dated March 12, 2021, relating to the financial statements of Pandion Therapeutics, Inc. (successor to Pandion Therapeutics Holdco LLC) appearing in the Annual Report on Form 10-K of Pandion Therapeutics, Inc. for the year ended December 31, 2020.

 

/s/ Deloitte & Touche LLP

Boston, Massachusetts

March 12, 2021