| | | | | | | | |
| Name of Subsidiary | | State of Jurisdiction or Organization |
| Depo DR Sub, LLC | | Delaware |
| ASIO Holdings, LLC | | Texas |
| Assertio Management, LLC | | Delaware |
| Assertio Distribution, LLC | | Delaware |
| Alligator IP, LLC | | Delaware |
| Zyla Life Sciences, LLC | | Delaware |
| Zyla Life Sciences US, LLC | | Delaware |
| Assertio Specialty Pharmaceuticals, LLC | | Delaware |
| Spectrum Pharmaceuticals, Inc. | | Delaware |
| Spectrum Pharmaceuticals International Holdings, LLC | | Delaware |
| Spectrum Oncology Private Limited | | India |
| Allos Therapeutics, Inc. | | Delaware |
| Talon Therapeutics, Inc. | | Delaware |