March 11, 2025

Jason Lettmann
Chief Executive Officer
ALX Oncology Holdings, Inc.
323 Allerton Avenue
South San Francisco, CA 94080

       Re: ALX Oncology Holdings, Inc.
           Registration Statement on Form S-3
           Filed March 6, 2025
           File No. 333-285620
Dear Jason Lettmann:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Lauren Hamill at 303-844-1008 with any questions.



                                                           Sincerely,

                                                           Division of
Corporation Finance
                                                           Office of Life
Sciences
cc:   Christina Poulsen