Comment for Type of Reporting Person:   These securities are held of record by TCG Crossover II (as defined in Item 2(a) below). TCG Crossover GP II (as defined in Item 2(a) below) is the general partner of TCG Crossover II and may be deemed to have voting, investment, and dispositive power with respect to these securities. Chen Yu is the sole managing member of TCG Crossover GP II and may be deemed to share voting, investment and dispositive power with respect to these securities. This total excludes 3,050,159 shares of Common Stock subject to Pre-Funded Warrants (the Pre-Funded Warrants) which are not exercisable within 60 days of this Statement because the Pre-Funded Warrants may not be exercised to the extent that doing so would result in the holder of the Pre-Funded Warrants (together with the holder's affiliates and any other persons acting as a group together with the holder or any of the holder's affiliates) beneficially owning more than 9.99 percent of the shares of Common Stock then outstanding immediately after giving effect to such exercise (the Beneficial Ownership Limitation). Based on 131,197,113 shares of Common Stock, as follows: (a) 54,218,001 shares of Common Stock outstanding as of October 31, 2025, as reported by the Issuer (as defined in Item 1(a) below) in its Quarterly Report on Form 10-Q, filed with the United States Securities and Exchange Commission (the Commission) on November 7, 2025 (the Form 10-Q), plus (b) 76,979,112 shares of Common Stock issued in an underwritten offering that closed on January 30, 2026, as reported in the Issuer's Current Report on Form 8-K, filed with the Commission on January 30, 2026 (the Offering).

Comment for Type of Reporting Person:   These securities are held of record by TCG Crossover II. TCG Crossover GP II is the general partner of TCG Crossover II and may be deemed to have voting, investment, and dispositive power with respect to these securities. Chen Yu is the sole managing member of TCG Crossover GP II and may be deemed to share voting, investment and dispositive power with respect to these securities. This total excludes 3,050,159 shares of Common Stock subject to Pre-Funded Warrants which are not exercisable within 60 days of this Statement due to the Beneficial Ownership Limitation. Based on 131,197,113 shares of Common Stock, as follows: (a) 54,218,001 shares of Common Stock outstanding as of October 31, 2025, as reported by the Issuer in the Form 10-Q, plus (b) 76,979,112 shares of Common Stock issued in the Offering.

Comment for Type of Reporting Person:   These securities are held of record by TCG Crossover III (as defined in Item 2(a) below). TCG Crossover GP III (as defined in Item 2(a) below) is the general partner of TCG Crossover III and may be deemed to have voting, investment, and dispositive power with respect to these securities. Chen Yu is the sole managing member of TCG Crossover GP III and may be deemed to share voting, investment and dispositive power with respect to these securities. This total excludes 3,050,158 shares of Common Stock subject to Pre-Funded Warrants which are not exercisable within 60 days of this Statement due to the Beneficial Ownership Limitation. Based on 131,197,113 shares of Common Stock, as follows: (a) 54,218,001 shares of Common Stock outstanding as of October 31, 2025, as reported by the Issuer in the Form 10-Q, plus (b) 76,979,112 shares of Common Stock issued in the Offering.

Comment for Type of Reporting Person:   These securities are held of record by TCG Crossover III. TCG Crossover GP III is the general partner of TCG Crossover III and may be deemed to have voting, investment, and dispositive power with respect to these securities. Chen Yu is the sole managing member of TCG Crossover GP III and may be deemed to share voting, investment and dispositive power with respect to these securities. This total excludes 3,050,158 shares of Common Stock subject to Pre-Funded Warrants which are not exercisable within 60 days of this Statement due to the Beneficial Ownership Limitation. Based on 131,197,113 shares of Common Stock, as follows: (a) 54,218,001 shares of Common Stock outstanding as of October 31, 2025, as reported by the Issuer in the Form 10-Q, plus (b) 76,979,112 shares of Common Stock issued in the Offering.

Comment for Type of Reporting Person:   Consists of (i) 6,505,925 shares of Common Stock held of record by TCG Crossover II and (ii) 6,505,924 shares of Common Stock held of record by TCG Crossover III. TCG Crossover GP II is the general partner of TCG Crossover II and may be deemed to have voting, investment, and dispositive power with respect to the securities held of record by TCG Crossover II. TCG Crossover GP III is the general partner of TCG Crossover III and may be deemed to have voting, investment, and dispositive power with respect to the securities held of record by TCG Crossover III. Chen Yu is the sole managing member of each of TCG Crossover GP II and TCG Crossover GP III and may be deemed to share voting, investment and dispositive power with respect to the securities held of record by TCG Crossover II and TCG Crossover III. This total excludes (i) 3,050,159 shares of Common Stock subject to Pre-Funded Warrants held by TCG Crossover II and (ii) 3,050,158 shares of Common Stock subject to Pre-Funded Warrants held by TCG Crossover III which are not exercisable within 60 days of this Statement due to the Beneficial Ownership Limitation. Based on 131,197,113 shares of Common Stock, as follows: (a) 54,218,001 shares of Common Stock outstanding as of October 31, 2025, as reported by the Issuer in the Form 10-Q, plus (b) 76,979,112 shares of Common Stock issued in the Offering.

Comments accompanying signature:   Exhibit 1 - Joint Filing Agreement