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Exhibit 21.1

Subsidiaries of Orchestra BioMed Holdings, Inc.

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State or

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Jurisdiction

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of Incorporation or

Name

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Organization

Orchestra BioMed, Inc.

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Delaware

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BackBeat Medical, LLC

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Delaware

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Caliber Therapeutics, LLC

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Delaware

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FreeHold Surgical, LLC

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Delaware

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Accelerated Technologies, LLC

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Delaware

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Motus GI, LLC

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Delaware

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Motus GI Medical Technologies, Ltd.

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Israel

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