Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in the following Registration Statements:
| (1) | Registration Statement (Form S-8 No. 333-271092) pertaining to the Orchestra BioMed Holdings, Inc. 2023 Equity Incentive Plan and the Orchestra BioMed, Inc. 2018 Stock Incentive Plan, |
| (2) | Registration Statement (Form S-3 No. 333-274924) of Orchestra BioMed Holdings, Inc., |
| (3) | Registration Statement (Form S-8 No. 333-278285) pertaining to the Orchestra BioMed Holdings, Inc. 2023 Equity Incentive Plan, |
| (4) | Registration Statement (Form S-3 No. 333-279430) Orchestra BioMed Holdings, Inc., |
| (5) | Registration Statement (Form S-8 No. 333-285058) pertaining to the Orchestra BioMed Holdings, Inc. 2023 Equity Incentive Plan, |
| (6) | Registration Statement (Form S-3 No. 333-291207) of Orchestra BioMed Holdings, Inc., |
| (7) | Registration Statement (Form S-8 No. 333-293267) pertaining to the Orchestra BioMed Holdings, Inc. 2023 Equity Incentive Plan, and |
| (8) | Registration Statement (Form S-8 No. 333-293268) pertaining to the Orchestra BioMed Holdings, Inc. 2025 New Hire Inducement Plan; |
of our report dated March 12, 2026, with respect to the consolidated financial statements of Orchestra BioMed Holdings, Inc. included in this Annual Report (Form 10-K) of Orchestra BioMed Holdings, Inc. for the year ended December 31, 2025.
/s/ Ernst & Young LLP | |
Philadelphia, Pennsylvania
March 12, 2026