Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in the following Registration Statements:
1.
Registration Statement (Form S-3ASR No. 333-279196) of Janux Therapeutics, Inc.,
2.
Registration Statement (Form S-8 No. 333-257039) pertaining to the 2017 Equity Incentive Plan (Prior Plan), the 2021 Equity Incentive Plan, and the 2021 Employee Stock Purchase Plan of Janux Therapeutics, Inc., and
3.
Registration Statements (Form S-8 Nos. 333-263712, 333-270470, 333-277797 and 333-285357) pertaining to the 2021 Equity Incentive Plan, and the 2021 Employee Stock Purchase Plan of Janux Therapeutics, Inc.;
of our reports dated February 26, 2026, with respect to the financial statements of Janux Therapeutics, Inc. and the effectiveness of internal control over financial reporting of Janux Therapeutics, Inc., included in this Annual Report (Form 10-K) of Janux Therapeutics, Inc. for the year ended December 31, 2025.
/s/ Ernst & Young LLP
San Diego, California
February 26, 2026