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Consent of Independent Registered Public Accounting Firm
We consent to the reference to our firm under the caption "Experts" in the Registration Statement (Form S-3) and related Prospectus of GeneDx Holdings Corp. for the registration of its Class A common stock, preferred stock, debt securities and warrants and to the incorporation by reference therein of our report dated February 20, 2025, with respect to the consolidated financial statements of GeneDx Holdings Corp. included in its Annual Report (Form 10-K) for the year ended December 31, 2024, filed with the Securities and Exchange Commission.
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| /s/ Ernst & Young LLP | |
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| New York, New York | |
| October 28, 2025 | |