Subsidiaries

Place of Incorporation

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Adagene (Hong Kong) Limited

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Hong Kong

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Adagene (Suzhou) Limited

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PRC

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Adagene Incorporated

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Delaware, United States

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ADAGENE PTE. LTD.

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Singapore

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ADAGENE AUSTRALIA PTY LTD

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Australia

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ADAGENE AG

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Switzerland

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Adagene Project C1 Pte. Ltd.

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Singapore

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Adagene (Suzhou) Limited Guangzhou Branch

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PRC