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Exhibit 15.4

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (No. 333-255250) and Form F-3 (No. 333-264486) of Adagene Inc. of our report dated March 24, 2025 relating to the financial statements, which appears in this Form 20-F.

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/s/PricewaterhouseCoopers Zhong Tian LLP

Shanghai, the People’s Republic of China

March 24, 2025

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