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                   Filed by the Registrant ☒ 
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                 Preliminary Proxy Statement 
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                 Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) 
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                 Definitive Proxy Statement 
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                 Definitive Additional Materials 
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                 Soliciting Material under §240.14a-12 
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                 SCIENCE 37 HOLDINGS, INC. 
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                 (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant) 
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             No fee required. 
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             Fee paid previously with preliminary materials. 
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             Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11. 
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