March 27, 2025

Robert Etherington
Chief Executive Officer
Clene Inc.
6550 South Millrock Drive, Suite G50
Salt Lake City, UT 84121

       Re: Clene Inc.
           Registration Statement on Form S-3
           Filed March 24, 2025
           File No. 333-286058
Dear Robert Etherington:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Lauren Hamill at 303-844-1008 with any questions.



                                                           Sincerely,

                                                           Division of
Corporation Finance
                                                           Office of Life
Sciences
cc:   Tom McAleavey