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GRI BIO, INC.

2223 AVENIDA DE LA PLAYA, SUITE 208

LA JOLLA, CA 92037

VIA EDGAR

March 26, 2025

U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attn: Daniel Crawford

Re:			GRI Bio, Inc.
			Registration Statement on Form S-1, as amended (File No. 333-286072)
			Request for Acceleration of Effective Date

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, GRI Bio, Inc. (the “Company”) hereby requests that the Securities and Exchange Commission accelerate the effective date of the above-referenced Registration Statement on Form S-1 (the “Registration Statement”) so that the Registration Statement will be declared effective as of 12:00 p.m. Eastern Time, on March 28, 2025, or as soon as practicable thereafter. The Company hereby authorizes Melanie Ruthrauff Levy or Jason Miller, both of whom are attorneys at the Company’s outside legal counsel, Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., to orally modify or withdraw this request for acceleration.

Once the Registration Statement has been declared effective, please orally confirm that event with Mrs. Levy at (858) 314-1873 or Mr. Miller at (858) 314-2140.

Thank you for your assistance in this matter.

Very truly yours,
GRI BIO, INC.
/s/ W. Marc Hertz, Ph.D.
W. Marc Hertz, Ph.D.
Chief Executive Officer

cc:			Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
			Adam Lenain, Esq.
			Melanie Ruthrauff Levy, Esq.
			Jason Miller, Esq.