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Exhibit 32.1

CERTIFICATION

Pursuant to the requirement set forth in Rule 13a-14(b) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and Section 1350 of Chapter 63 of Title 18 of the United States Code (18 U.S.C. §1350), Niccolo M. de Masi, Chairman, President and Chief Executive Officer of IonQ, Inc. (the “Company”), and Inder M. Singh, Chief Financial Officer and Chief Operating Officer of the Company, each hereby certifies that, to the best of his knowledge:

1.
The Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2025, to which this Certification is attached as Exhibit 32.1 (the “Annual Report”), fully complies with the requirements of Section 13(a) or Section 15(d) of the Exchange Act; and
2.
The information contained in the Annual Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

IN WITNESS WHEREOF, the undersigned have set their hands hereto as of the 25th day of February 2026.

 

/s/ Niccolo M. de Masi

 

/s/ Inder M. Singh

Niccolo M. de Masi

 

Inder M. Singh

Chairman, President and Chief Executive Officer

 

Chief Financial Officer and Chief Operating Officer