Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the reference to our firm under the caption “Experts” and to the use of our report dated March 26, 2024, in post-effective Amendment No.3 to the Registration Statement (Form S-1 No. 333-262339) and related Prospectus of eFFECTOR Therapeutics, Inc. for the registration of up to 296,136 shares of its common stock.

/s/ Ernst & Young LLP

San Diego, California

March 29, 2024