Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in the following Registration Statements:
| (1) | Registration Statement (Form S-8 No. 333-260460) pertaining to the 2020 Stock Incentive Plan, 2021 Stock Incentive Plan, and 2021 Employee Stock Purchase Plan of Xilio Therapeutics, Inc., |
| (2) | Registration Statement (Form S-8 No. 333-263178) pertaining to the 2021 Stock Incentive Plan and 2021 Employee Stock Purchase Plan of Xilio Therapeutics, Inc., |
| (3) | Registration Statement (Form S-3 No. 333-268264) of Xilio Therapeutics, Inc., |
| (4) | Registration Statement (Form S-8 No. 333-270240) pertaining to the 2021 Stock Incentive Plan, 2021 Employee Stock Purchase Plan, and 2022 Inducement Stock Incentive Plan of Xilio Therapeutics, Inc., |
| (5) | Registration Statement (Form S-8 No. 333-278427) pertaining to the 2021 Stock Incentive Plan and 2021 Employee Stock Purchase Plan of Xilio Therapeutics, Inc., and |
| (6) | Registration Statement (Form S-3 No. 333-279015) of Xilio Therapeutics, Inc.; |
of our report dated March 11, 2025, with respect to the consolidated financial statements of Xilio Therapeutics, Inc. included in this Annual Report (Form 10-K) of Xilio Therapeutics, Inc. for the year ended December 31, 2024.
/s/ Ernst & Young LLP | |
Boston, Massachusetts |
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March 11, 2025 |
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