Exhibit 15.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in the Registration Statement on Form S-8 (No. “333-256655”) of LAVA Therapeutics N.V. of our report dated March 24, 2022 relating to the financial statements, which appears in this Form 20-F.

/s/ R.M.N. Admiraal RA

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PricewaterhouseCoopers Accountants N.V.

Eindhoven, The Netherlands

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March 24, 2022